{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:54:11Z","timestamp":1784919251018,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Studies on bone and joint infections (BJI) in infants under three months are rare. We described the clinical and paraclinical features and outcomes of infants hospitalised with BJI under three months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The French National Hospital Discharge Database provided data on BJIs in infants under three months of age from January 2004 to 2015 in three Parisian Paediatric teaching hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 71 infants under three months of age with BJI, the median age was 25\u00a0days, and the interquartile range (IQR) was 17\u201343\u00a0days. The most common infection sites were the hip (32%) and knee (32%). Symptoms included pain (94%), limited mobility (87%) and\/or fever (52%). There were 11 (15.5%) cases of nosocomial BJI. A pathogen was identified in 51 infants (71.8%), including<jats:italic>Streptococcus agalactiae<\/jats:italic>(45%),<jats:italic>Staphylococcus aureus<\/jats:italic>(22%) and<jats:italic>Escherichia coli<\/jats:italic>(18%). The initial median C\u2010reactive protein test rate was 31\u00a0mg\/L (IQR 17\u201368). Of the 34 infants followed for more than one year, four developed severe orthopaedic conditions such as epiphysiodesis, limb length discrepancy, bone necrosis and\/or impaired limb function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Streptococcus agalactiae<\/jats:italic>was the most common cause of BJI in infants under three months. Orthopaedic sequelae were rare, but severe, and required long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14569","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T15:02:18Z","timestamp":1536246138000},"page":"933-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bone and joint infections in infants under three months of age"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-5878","authenticated-orcid":false,"given":"Nicolas","family":"Mediamolle","sequence":"first","affiliation":[{"name":"Paediatric Department\u2010Division of infectious disease Armand Trousseau Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Mallet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedic Surgery Robert Debr\u00e9 Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Aupiais","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Care Inserm U1123 and CIC\u2010EC 1426, Inserm, U1138, Equipe 22 Robert Debr\u00e9 Hospital AP\u2010HP Universit\u00e9 Paris Diderot Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Doit","sequence":"additional","affiliation":[{"name":"Department of Microbiology Associated\u2010National Reference Center for Escherichia Coli UMR 1137, INSERM Robert Debr\u00e9 Hospital APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Ntika","sequence":"additional","affiliation":[{"name":"Pediatric Department Centre hospitalier de Blois Blois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Vialle","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedic Surgery Armand Trousseau Hospital APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Grimprel","sequence":"additional","affiliation":[{"name":"Paediatric Department\u2010Division of infectious disease Armand Trousseau Hospital, AP\u2010HP Paris France"},{"name":"GPIP, Groupe de Pathologie Infectieuse P\u00e9diatrique Soci\u00e9t\u00e9 Fran\u00e7aise de P\u00e9diatrie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zagorka","family":"Pejin","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Surgery Necker\u2010Enfants\u2010Malades Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Department of Microbiology Associated\u2010National Reference Center for Escherichia Coli UMR 1137, INSERM Robert Debr\u00e9 Hospital APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathie","family":"Lorrot","sequence":"additional","affiliation":[{"name":"Paediatric Department\u2010Division of infectious disease Armand Trousseau Hospital, AP\u2010HP Paris France"},{"name":"GPIP, Groupe de Pathologie Infectieuse P\u00e9diatrique Soci\u00e9t\u00e9 Fran\u00e7aise de P\u00e9diatrie Paris France"},{"name":"Inserm UMR 1123 ECEVE Sorbonne Paris Cit\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1413-8670(10)70085-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954084"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"Kiechl\u2010KohlendorferU GriesmaierE.Neonatal osteomyelitis.2013. 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