{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:42:52Z","timestamp":1769157772767,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study determined cardiovascular impairment in young children with obstructive respiratory disease who were assessed using the opening interrupter technique (RINT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pilot study enrolled 41 children who had been referred to pulmonology and allergology specialists at the University of Catania, Italy, from March to July 2017: 23 (mean age 4.13\u00a0\u00b1\u00a00.62\u00a0years) had chronic coughs and wheezing and 18 controls (mean age 4.27\u00a0\u00b1\u00a00.66\u00a0years) had obstructive chest disease, but were otherwise healthy. Airway resistance was evaluated using RINT and cardiac function by studying the ejection fraction, pulmonary artery systolic pressure (PASP), tricuspid annular plane systolic excursion and tricuspid flow propagation velocity (TFPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The RINT and PASP values were significantly higher in the patient group when compared to the controls, but the TFPV values were lower. A direct and significant Spearman's correlation coefficient (<jats:italic>r<\/jats:italic>) between RINT and PASP values was observed (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.81). We found a significant inverse correlation between RINT and TFPV (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.83), as well as TFPV and PASP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that children with obstructive respiratory diseases had a major risk of cardiovascular impairment. Impaired diastolic function of the right ventricle occurred very early when airway resistance was abnormally increased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14574","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T13:49:15Z","timestamp":1536414555000},"page":"740-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pilot study shows right ventricular diastolic function impairment in young children with obstructive respiratory disease"],"prefix":"10.1111","volume":"108","author":[{"given":"S","family":"Manti","sequence":"first","affiliation":[{"name":"Department of Pediatrics Unit of Pediatric Genetics and Immunology University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-0195","authenticated-orcid":false,"given":"G F","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department 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