{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:21:31Z","timestamp":1789021291590,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p><jats:italic>Klebsiella<\/jats:italic> spp. have been stated to be the most frequent cause of neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>) outbreaks. We report an outbreak of <jats:italic>Klebsiella oxytoca<\/jats:italic> in a <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> at a tertiary care hospital in Norway between April 2016 and April 2017. This study describes the outbreak, infection control measures undertaken and the molecular methods developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The outbreak prompted detailed epidemiological and microbial investigations, where whole\u2010genome sequencing (<jats:styled-content style=\"fixed-case\">WGS<\/jats:styled-content>) was particularly useful for both genotyping and development of two new <jats:italic>K.\u00a0oxytoca<\/jats:italic>\u2010specific real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assays. Routine screening of patients, as well as sampling from numerous environmental sites, was performed during the outbreak. A bundle of infection control measures was instigated to control the outbreak, among them strict cohort isolation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five neonates had symptomatic infection, and 17 were found to be asymptomatically colonised. Infections varied in severity from conjunctivitis to a fatal case of pneumonia. A source of the outbreak could not be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report describes <jats:italic>K.\u00a0oxytoca<\/jats:italic> as a significant pathogen in a <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> outbreak setting and highlights the importance of developing appropriate microbiological screening methods and implementing strict infection control measures to control the outbreak in a setting where the source could not be identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14584","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T12:37:23Z","timestamp":1537533443000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Investigation of an outbreak caused by antibiotic\u2010susceptible <i>Klebsiella oxytoca<\/i> in a neonatal intensive care unit in Norway"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4686-7614","authenticated-orcid":false,"given":"Torunn Gresdal","family":"R\u00f8nning","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Gabrielsen","family":"Aas","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"},{"name":"Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"St\u00f8en","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences Norwegian University of Science 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