{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:16:07Z","timestamp":1768562167951,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate cerebral autoregulation changes in preterm infants receiving a loading dose of caffeine base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cohort of 30 preterm infants, we extracted measures of cerebral autoregulation using time and frequency domain techniques to determine the correlation between mean arterial pressure (MAP) and tissue oxygenation index (TOI) signals. These measures included the cerebral oximetry index (COx), cross\u2010correlation and coherence measures, and were extracted prior to caffeine loading and in the 2\u00a0hours following administration of 10\u00a0mg\/kg caffeine base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed acute reductions in time domain correlation measures, including the cerebral oximetry index (linear mixed model coefficient \u22120.093, standard error 0.04; p\u00a0=\u00a00.028) and the detrended cross\u2010correlation coefficient (\u03c1<jats:sub>5<\/jats:sub> coefficient \u22120.13, standard error 0.055; p\u00a0=\u00a00.025). These reductions suggested an acute improvement in cerebral autoregulation. Features from detrended cross\u2010correlation analysis also showed greater discriminative value than other methods in identifying changes prior to and following caffeine administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a reduced correlation between MAP and TOI from near\u2010infrared spectroscopy following caffeine administration. These findings suggest an acute enhanced capacity for cerebral autoregulation following a loading dose of caffeine in preterm infants, contributing to our understanding of the physiological impact of caffeine therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14636","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T14:04:18Z","timestamp":1541599458000},"page":"436-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of caffeine loading on cerebral autoregulation in preterm infants"],"prefix":"10.1111","volume":"108","author":[{"given":"Jacqueline","family":"Huvanandana","sequence":"first","affiliation":[{"name":"School of Electrical and Information Engineering University of Sydney Sydney NSW Australia"},{"name":"Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Thamrin","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Hinder","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering University of Sydney Sydney NSW Australia"},{"name":"Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair","family":"McEwan","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering University of Sydney Sydney NSW Australia"},{"name":"Cerebral Palsy Alliance Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-468X","authenticated-orcid":false,"given":"Mark B.","family":"Tracy","sequence":"additional","affiliation":[{"name":"Westmead Hospital Sydney NSW Australia"},{"name":"School of Paediatrics and Child Health University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e31803237f6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80373-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485706"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3426323"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.238"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.H233"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1995.tb00111.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1707"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073679"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0238"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01828.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14382"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-016-3345-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.169"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.3.037009"},{"key":"e_1_2_10_19_1","volume-title":"An analytical method for determining cerebrovascular transit time using near infrared spectroscopy. 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