{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:49:13Z","timestamp":1766087353609,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the weight, insulin\u2010like growth factor\u20101, neonatal, retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content>) algorithm for very premature infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Infants born before 32\u00a0weeks who had undergone fundus examinations in the neonatal intensive care unit at the University Hospital of Nancy were included in this French retrospective cohort study from July 2012 to July 2016. We evaluated how well the <jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content> software predicted threshold retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 570 infants with a mean gestational age of 28.7\u00a0\u00b1\u00a01.8\u00a0weeks and a mean birth weight of 1110\u00a0\u00b1\u00a0297\u00a0g: 28.1% had <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> and 1.2% had threshold <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. The overall <jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content> sensitivity was 57.1%, specificity was 46.0%, predictive positive value was 1.3% and predictive negative value was 98.9%. At more than 30\u00a0weeks of gestation or 1250\u00a0g, these figures rose to a respective specificity of 100% and 95.7% and respective predictive negative value of 100% and 100%. There were independent associations between the severity of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> and the Apgar score at five minutes, the duration of oxygen therapy and non\u2010invasive ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content> worked better on preterm infants born from 31\u00a0weeks onwards or weighing over 1250\u00a0g. Fundus examinations remain necessary for infants born earlier or lighter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14654","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T11:17:15Z","timestamp":1542799035000},"page":"1049-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Algorithm for predicting threshold retinopathy of prematurity is insufficient and fundus examinations are still needed before 31 weeks"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-6453","authenticated-orcid":false,"given":"M","family":"Wirth","sequence":"first","affiliation":[{"name":"Department of Neonatology University Hospital of Nancy Nancy France"},{"name":"EA3450 \u2010 DevAH University of Lorraine Vandoeuvre les Nancy 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