{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T22:47:29Z","timestamp":1768171649351,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"I Colori della Vita Foundation, Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Near\u2010infrared spectroscopy (<jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content>) has been proposed to provide reliable information concerning brain oximetry and tissue activation level in the perinatal period. We aimed to investigate whether <jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content> brain patterns in healthy preterm (PT) and term (T) infants were gender\u2010 and gestational age (GA)\u2010dependent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational study in 74 newborns, from consecutive singleton pregnancies, of whom 37 were born at term (male: n\u00a0=\u00a019 female: n\u00a0=\u00a018) and 37 (male: n\u00a0=\u00a018 female: n\u00a0=\u00a019) were PT. Cerebral oximetry (cr<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub>) and fractional tissue oxygen extraction (<jats:styled-content style=\"fixed-case\">cFTOE<\/jats:styled-content>), were recorded on the 5th day from birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>cr<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> was significantly higher and <jats:styled-content style=\"fixed-case\">cFTOE<\/jats:styled-content> lower (p\u00a0&lt;\u00a00.001, for both) in the PT female than male group. At term, cr<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> was significantly higher and <jats:styled-content style=\"fixed-case\">cFTOE<\/jats:styled-content> lower (p\u00a0&lt;\u00a00.001, for both) in males. cr<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> (male: R\u00a0=\u00a00.84, p\u00a0&lt;\u00a00.001; female: R\u00a0=\u00a00.74, p\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">cFTOE<\/jats:styled-content> (male: R\u00a0=\u00a00.72, p\u00a0&lt;\u00a00.001; female: R\u00a0=\u00a00.72, p\u00a0&lt;\u00a00.001) in male and female groups correlated positively with GA at recording.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Different brain oximetry between males and females in PT a T infants, may suggest that in the perinatal period brain development is gender\u2010 and time\u2010dependent. Data support the use of <jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content> as a feasible tool for non\u2010invasive cerebral monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14655","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T11:17:50Z","timestamp":1542799070000},"page":"1036-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NIRS cerebral patterns in healthy late preterm and term infants are gender\u2010 and gestational age\u2010dependent"],"prefix":"10.1111","volume":"108","author":[{"given":"Alice","family":"Grometto","sequence":"first","affiliation":[{"name":"Faculty of Biology University of Pavia Pavia Italy"},{"name":"Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pluchinotta","sequence":"additional","affiliation":[{"name":"Laboratory Research Department of Paediatric Cardiovascular Surgery San Donato Milanese University Hospital San Donato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Magna Grecia University Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Strozzi","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-2555","authenticated-orcid":false,"given":"Diego","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital Alessandria Italy"},{"name":"Neonatal Intensive Care Unit G. D'Annunzio University of Chieti Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140036"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800221105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410024998"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2762"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2009.06.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.02.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7030024"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08459-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.7.998"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.12.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6163211"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2006.02.006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308843"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00353.2015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.186"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12550.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101063"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14099"},{"key":"e_1_2_10_23_1","first-page":"21","volume-title":"Psychobiology of human newborn","author":"Prechtl HFR","year":"1982"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.09.014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1037\/0033-2909.118.1.55","article-title":"Human behavioural sex differences: a role for gonadal hormones during early development?","volume":"118","author":"Collaer ML","year":"1995","journal-title":"Psychol Bull"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720209788970090"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20453"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430213"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.4\/jmarrocco"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23809"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6259728"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.051"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2741\/e78"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0987"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.14655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.14655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:30:15Z","timestamp":1693830615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.14655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/apa.14655"],"URL":"https:\/\/doi.org\/10.1111\/apa.14655","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]},"assertion":[{"value":"2018-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}