{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:19:25Z","timestamp":1771543165949,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Meta\u2010analyses of randomised controlled trials on infant bronchiolitis do not support medication. We summarised the current data and evaluated the real\u2010life use of medication for infants treated for bronchiolitis in hospitals, including paediatric wards, emergency departments and paediatric intensive care units (<jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed for studies published from 2009 to 2018 that provided data on the real\u2010life use of adrenaline, salbutamol, corticosteroids or antibiotics for infants hospitalised for bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The review identified 10 such studies and showed substantial variations in medication for infant bronchiolitis between different countries and even between different hospitals in the same country. A multi\u2010centre study including 38 hospitals in eight countries reported that a mean of 29% infants admitted for bronchiolitis received drugs without any research\u2010based evidence on their effectiveness, ranging from 9% in Australia and New Zealand to 58% in Spain and Portugal. In addition, an American prospective multi\u2010centre study of 16 <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>s reported that bronchodilators were used by a mean of 60%, corticosteroids by 33% and antibiotics by 63%. Other studies reported that higher ages and a history of wheezing increased the use of medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were substantial variations in bronchiolitis treatment between, and within, different countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14713","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:34:17Z","timestamp":1546979657000},"page":"1016-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Review shows substantial variations in the use of medication for infant bronchiolitis between and within countries"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-1919","authenticated-orcid":false,"given":"Matti","family":"Korppi","sequence":"first","affiliation":[{"name":"Center for Child health Research Tampere University Hospital University of Tampere Tampere 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