{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:41:29Z","timestamp":1770741689408,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>European consensus guidelines published in May 2013 recommended a target peripheral capillary oxygen saturation (SpO<jats:sub>2<\/jats:sub>) range of 90\u201395% for preterm infants. These were incorporated into guidelines at the Karolinska University Hospital, Sweden, in November 2013. This study compared clinical practice before and after those local guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included infants who were born between 23\u00a0+\u00a00 and 30\u00a0+\u00a06\u00a0weeks from January 1, 2013 to December, 31 2015 and received intensive care in two Karolinska units. The lower saturation target of 88\u201392% and alarm limits of 85\u201395% used before November 2013 were compared to the new higher saturation target of 90\u201395% and alarm limits of 89\u201396%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 399 infants were analysed. The mean SpO<jats:sub>2<\/jats:sub> was 92.4% with the higher target (n\u00a0=\u00a0301) and 91.1% with the lower target (n\u00a0=\u00a098). Using the higher instead of lower target meant that the SpO<jats:sub>2<\/jats:sub> was within the prescribed target range more frequently (51% versus 30%) and the proportion of time with SpO<jats:sub>2<\/jats:sub> &gt;95% was increased by 9% (95% confidence interval 7\u201311%, p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The higher saturation target and tighter alarm limits led to higher mean oxygen saturation, increased adherence to the target and increased time with hyperoxaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14808","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T09:38:07Z","timestamp":1554543487000},"page":"1584-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adherence to oxygen saturation targets increased in preterm infants when a higher target range and tighter alarm limits were introduced"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-6502","authenticated-orcid":false,"given":"S","family":"Klevebro","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden"},{"name":"Sachs\u2019 Children and Youth Hospital South General Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Hammar","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Ophthalmology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bottai","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hallberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Neonatal Medicine Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"143","article-title":"Oxygen use in neonatal care: a two\u2010edged sword","volume":"4","author":"Perrone S","year":"2016","journal-title":"Front Pediatr"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0391"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282153"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211608"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2006.04.010"},{"key":"e_1_2_10_8_1","first-page":"78","article-title":"A physiologic reduced oxygen protocol decreases the incidence of threshold retinopathy of prematurity","volume":"104","author":"Wright KW","year":"2006","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000297773"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000349928"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911781"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1101319"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1994.02170030064015"},{"key":"e_1_2_10_15_1","unstructured":"GouldW.crc36: clarification on analytic weights with linear regression. 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