{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:29Z","timestamp":1787013869409,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      We sought to evaluate the associations between umbilical artery\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      and base excess and neurodevelopmental outcome at four years of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study comprised 84\u00a0588 singleton children born alive at term in 2005\u20132011 in the hospital district of Helsinki and Uusimaa in Finland. Data from the maternity hospital information system were linked to the data from the Medical Birth Register and the Hospital Discharge Register. Neurodevelopmental morbidity included cerebral palsy, epilepsy, intellectual or sensorineural impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for maternal and perinatal factors, a combination of\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      &lt;7.00 and base excess &lt;\u221216.00 was associated with infant death (adjusted odds ratio 19.97; 95% confidence interval 5.38\u201374.17). Values of\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      7.00\u20137.10 were associated with cerebral palsy (adjusted odds ratio 2.40; 95% confidence interval 1.05\u20135.47). A combination of low five\u2010minute Apgar score and umbilical artery base excess &lt;\u221216.00 showed the highest positive predictive value (9.1%) for neurodevelopmental impairments. When umbilical artery\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      &lt;7.00 was included, a positive predictive value of 25.0% was observed for infant mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Low umbilical artery\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      and base excess at birth were the poor predictors of long\u2010term neurodevelopmental morbidity in an unselected population. However, these parameters might be useful in assessing the risk of infant mortality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.14812","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T13:43:51Z","timestamp":1554644631000},"page":"1801-1810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Umbilical artery\n                    <scp>pH<\/scp>\n                    and base excess at birth are poor predictors of neurodevelopmental morbidity in early childhood"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-2169","authenticated-orcid":false,"given":"Elina","family":"Leinonen","sequence":"first","affiliation":[{"name":"Children's Hospital Paediatric Research Centre Helsinki University Hospital University of Helsinki Helsinki 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