{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:47:26Z","timestamp":1792446446507,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate long\u2010term cognitive and behavioural outcomes of children with neonatal hypoxic\u2013ischaemic encephalopathy (HIE) in the absence of cerebral palsy (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was performed on five databases (<jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Medline, PubMed, Web of Science, PsycInfo). Randomised controlled trials, non\u2010randomised controlled trials, or observational studies, published between 1990 and 2017, that reported long\u2010term (age greater than or equal to four years) cognitive and\/or behavioural outcomes of neonatal HIE without CP were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven articles met the inclusion criteria (n\u00a0=\u00a0352 total participants, n\u00a0=\u00a053 treated with therapeutic hypothermia). Studies reporting cognitive outcome demonstrate impairment of general cognitive abilities in 25\u201363% of participants with HIE without CP. Specific cognitive difficulties were reported in two studies for attention, executive functioning, memory function and language. Results regarding behavioural outcome possibly indicate a higher risk of difficulties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A substantial proportion of children with neonatal <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> who survive without CP are at increased risk of general and\/or specific cognitive impairments. Behavioural problems may be more common, but evidence is limited. Results highlight the importance of comprehensive long\u2010term follow\u2010up to identity difficulties and enable intervention to optimise educational achievement and behavioural adjustment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14821","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T11:11:02Z","timestamp":1555672262000},"page":"20-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Systematic review: long\u2010term cognitive and behavioural outcomes of neonatal hypoxic\u2013ischaemic encephalopathy in children without cerebral palsy"],"prefix":"10.1111","volume":"109","author":[{"given":"Magdalena","family":"Schreglmann","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine Southampton Children's Hospital University Hospital Southampton NHS Foundation Trust Southampton UK"},{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ground","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton UK"},{"name":"Paediatric and Neonatal Neurology Southampton Children's Hospital University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-9912","authenticated-orcid":false,"given":"Mark J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Southampton Children's Hospital University Hospital Southampton NHS Foundation Trust Southampton UK"},{"name":"National Institute for Health Research Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_11_3_1","first-page":"2017","volume-title":"Monitoring health for the SDGs. 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