{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:59Z","timestamp":1770815879520,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["VLL\u2010662391"],"award-info":[{"award-number":["VLL\u2010662391"]}],"id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Vaccine\u2010preventable pathogens causing severe childhood infections include <jats:italic>Haemophilus influenzae<\/jats:italic> type b (Hib), <jats:italic>Streptococcus pneumoniae<\/jats:italic> and <jats:italic>Neisseria meningitidis<\/jats:italic>. In this study conducted in a Swedish Arctic region, we evaluated the effects of general infant Hib and pneumococcal vaccination on invasive infectious diseases among children and assessed the need of meningococcal vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified cases of bacterial meningitis and sepsis from diagnosis and laboratory registers in the V\u00e4sterbotten Region, Sweden, during 1986\u20132015. We then reviewed medical records to confirm the diagnosis and extract data for assessing incidence changes, using an exploratory data analysis and a time\u2010series analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Invasive Haemophilus disease declined by 89.1% (p\u00a0&lt;\u00a00.01), Haemophilus meningitis by 95.3% (p\u00a0&lt;\u00a00.01) and all\u2010cause bacterial meningitis by 82.3% (p\u00a0&lt;\u00a00.01) in children aged 0 to four years following general infant Hib vaccination. Following pneumococcal vaccination, invasive pneumococcal disease declined by 84.7% (p\u00a0&lt;\u00a00.01), pneumococcal meningitis by 67.5% (p\u00a0=\u00a00.16) and all\u2010cause bacterial meningitis by 48.0% (p\u00a0=\u00a00.23). Incidence of invasive meningococcal disease remained low during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Remarkable sustained long\u2010term declines of invasive infectious diseases in younger children occurred following infant Hib and pneumococcal vaccinations in this Swedish Arctic region. Despite not offering general infant meningococcal vaccination, incidence of invasive meningococcal disease remained low.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14824","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T08:36:48Z","timestamp":1556267808000},"page":"1871-1878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sustained reductions of invasive infectious disease following general infant <i>Haemophilus influenzae<\/i> type b and pneumococcal vaccination in a Swedish Arctic region"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-2321","authenticated-orcid":false,"given":"Urban","family":"Johansson Kostenniemi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Department of Clinical Microbiology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Sellin","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven\u2010Arne","family":"Silfverdal","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/314535"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540510012800"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365549609049069"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007199"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-013-0051-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31824de9f6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.03.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.04.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1401.071315"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181bdbed5"},{"key":"e_1_2_11_12_1","unstructured":"Sametinget.Analysis of S\u00e1pmi. 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