{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:32:41Z","timestamp":1771036361733,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Rotaviruses have been associated with biliary atresia. This study investigated whether the rotavirus vaccine, which was introduced to Korea in 2008, had an impact on the incidence of biliary atresia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all rotavirus infections (n\u00a0=\u00a0436\u00a0826) and biliary atresia cases (n\u00a0=\u00a0528) diagnosed from 2006 to 2015 from insurance and health databases. The annual and seasonal incidence of biliary atresia and rotavirus infection rates in neonates and children were calculated. The difference in the risk of biliary atresia between rotavirus\u2010infected and non\u2010infected neonates was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of rotavirus infections was 20.6 versus 13.4 per 1000 cases before (2006\u20132008) and after (2009\u20132015) vaccine implementation. However, neonatal rotavirus infection rates did not decrease, with an incidence of 14.5 versus 14.8 per 1000 cases before and after vaccination. The biliary atresia incidence remained constant at 12.0 per 100\u00a0000 cases. Rotavirus infections in neonates were a risk factor for biliary atresia (odds ratio 3.14, 95% confidence interval 1.87\u20135.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rotavirus vaccination had no impact on the incidence of biliary atresia, possibly because the vaccination did not change the neonatal rotavirus infection rate through herd immunity. However, rotavirus infections in neonates were significantly associated with biliary atresia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14830","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T11:45:54Z","timestamp":1556538354000},"page":"2278-2284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nationwide population\u2010based study showed that the rotavirus vaccination had no impact on the incidence of biliary atresia in Korea"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-2487","authenticated-orcid":false,"given":"Jee Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Paediatrics College of Medicine Korea University Ansan Hospital Korea University Ansan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Sik","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine Korea University Seongbuk\u2010gu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Public Health Graduate School Korea University Seongbuk\u2010gu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather S.","family":"Swan","sequence":"additional","affiliation":[{"name":"School of Sociology and Anthropology University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics College of Medicine Korea University Ansan Hospital Korea University Ansan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine Korea University Seongbuk\u2010gu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230652"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60946-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318282a913"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-128"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329899"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0774-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32834c7ae4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.1.8"},{"key":"e_1_2_11_10_1","first-page":"394","article-title":"Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice","volume":"33","author":"Riepenhoff\u2010Talty M","year":"1993","journal-title":"Pediatr Res"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02094-06"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.09.033"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.05.034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181646730"},{"key":"e_1_2_11_15_1","unstructured":"KCDC.KCfDCaP. 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