{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:12:40Z","timestamp":1766391160762},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the accuracy of our new rapid point\u2010of\u2010care (<jats:styled-content style=\"fixed-case\">POC<\/jats:styled-content>) test for lung maturity. The method as we describe in an accompanying article was developed with the purpose of improving the outcome from respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>). The test enables the delivery of surfactant in infants with immature lungs already at birth and ensures that infants with mature lungs are not treated unnecessarily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fresh gastric aspirate (<jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>) was sampled at birth in a cohort of preterm infants with gestational ages ranging between 24 and 31 completed weeks for lung surfactant measurement as lecithin\u2013sphingomyelin ratio (L\/S). L\/S was prospectively compared with <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> development. The clinical outcome was blinded for the investigators of L\/S. The time for analysis was &lt;15\u00a0minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content> was obtained from 72 infants. Forty\u2010four (61%) developed <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>. The cut\u2010off for L\/S was 3.05; predicting <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> with a sensitivity of 91% and specificity of 79%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new improved spectroscopic L\/S method of lung maturity on <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content> has high sensitivity. The method is designed for use as a <jats:styled-content style=\"fixed-case\">POC<\/jats:styled-content> test at birth, and a spectroscopic prototype has been developed for bedside use. Clinical trials with this new lung maturity test are planned.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14831","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T03:11:25Z","timestamp":1556680285000},"page":"285-290","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates: 2. 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