{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:56:01Z","timestamp":1773258961056,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether non\u2010obese prepubertal children with growth hormone deficiency (GHD) present changes in lipid metabolism, and adipokines, and to assess the short\u2010term effects of growth hormone (GH) treatment on these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective observational follow\u2010up and case\u2013control (36 GHD children and 38 healthy children) study lasted for six months. Means of values from groups were compared, control group versus GHD baseline group, and GHD baseline group versus GHD after six months of GH replacement therapy. Lipid profile, glucose, insulin, homeostatic model assessment \u2013 insulin resistance (HOMA\u2010IR), leptin, adiponectin and soluble intercellular adhesion molecule\u20101 (sICAM\u20101) were all analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Growth hormone deficiency children show higher baseline levels of total cholesterol, LDL cholesterol, triglycerides, Apo B and sICAM\u20101, but lower levels of free fatty acids, insulin and HOMA\u2010IR. After six months of treatment, cholesterol, LDL cholesterol, Apo B, T cholesterol\/HDL cholesterol, insulin, HOMA\u2010IR and leptin levels decreased. The changes in insulin and HOMA\u2010IR levels correlated inversely with the changes in HDL cholesterol and Apo A1 levels. A correlation was also observed between the changes in adiponectin levels and the changes in HDL cholesterol and Apo A1 levels. Variations in leptin levels were correlated with changes in triglycerides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prepubertal non\u2010obese GHD children present altered lipid profiles and adipokine levels. Replacement therapy with GH improves these variables.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14849","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T01:45:10Z","timestamp":1557798310000},"page":"2027-2033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of growth hormone therapy on metabolic parameters, adipokine and endothelial dysfunction in prepuberal children"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8296-1846","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Ca\u00f1ete","sequence":"first","affiliation":[{"name":"Maimonides Institute of Biomedical Research of C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Valle\u2010Martos","sequence":"additional","affiliation":[{"name":"University of C\u00f3rdoba C\u00f3rdoba 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