{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:16:34Z","timestamp":1790864194196,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the frequency of <jats:italic>Mycoplasma pneumoniae<\/jats:italic> in nasopharyngeal specimens from children with respiratory tract infections (RTIs) and to detail clinical characteristics and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a retrospective cohort study. All children with RTI and nucleic acid amplification testing from nasopharyngeal specimens were analysed. Clinical data were extracted from electronic health records for all <jats:italic>M.\u00a0pneumoniae\u2010<\/jats:italic>positive cases. Stored samples of cases and a random selection of matched controls were retested using a <jats:italic>M.\u00a0pneumoniae\u2010specific<\/jats:italic> nucleic acid amplification test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4460 children, 70 (1.6%) were positive for <jats:italic>M.\u00a0pneumoniae <\/jats:italic>with a median age of 6.4 (IQR: 2.7\u20139.7). <jats:italic>M.\u00a0pneumoniae<\/jats:italic> was the only organism identified in 50\/64 (78%) cases. Macrolide treatment was prescribed in 52\/65 (80%); prescription was empirical in 29\/52 (56%) and targeted in 23\/52 (44%) with no difference regarding patient age, oxygen requirement or duration of hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:italic>M.\u00a0pneumoniae<\/jats:italic> in nasopharyngeal specimens of children with RTI was low. The detection of <jats:italic>M.\u00a0pneumoniae<\/jats:italic> influenced antibiotic prescriptions, but the benefit of early empirical versus targeted treatment remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14891","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T04:28:30Z","timestamp":1559795310000},"page":"375-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Mycoplasma pneumoniae<\/i> detection in children with respiratory tract infections and influence on management \u2013 a retrospective cohort study in Switzerland"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-8797","authenticated-orcid":false,"given":"Alexa","family":"Dierig","sequence":"first","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Vaccinology University of Basel Children\u2019s Hospital Basel 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