{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:33:32Z","timestamp":1792215212526,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Severe forms of idiopathic nephrotic syndrome (INS) require immunosuppressive therapy: oral treatment or intravenous therapy (rituximab, RTX). The main objective was to describe quality of life (QOL) in these specific patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional, multicentre, observational study analysed QOL using a standardised questionnaire in children from 7 to 17\u00a0years, with a steroid\u2010dependent or steroid\u2010resistant INS in stable remission. The questionnaire consisted of 30 questions concerning physical and emotional well\u2010being, self\u2010esteem, family, friends, school and disease resulting in a global score of 0\u2010100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 110 patients with a mean age of 11.6\u00a0years from three French paediatric nephrology centres were included. A total of 71 patients had oral immunosuppressive treatment, 27 had RTX, and 12 had both. 13.6% of patients had a steroid\u2010resistant INS. The mean number of relapses was 5.8. Seventy\u2010eight patients answered the questionnaire. The global score in the whole study population was 74.7; 72.6 in the RTX group, 76.2 in the oral drugs group, (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.49). The results of sub\u2010dimension \u2018school\u2019 were statistically lower in RTX group (61.6\u00a0\u00b1\u00a019.5) compared with oral drugs group (71.4\u00a0\u00b1\u00a016; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Global QOL score was high in \u2018difficult\u2010to\u2010treat\u2019 patients with INS in stable remission on oral immunosuppressive or RTX treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14912","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T06:53:23Z","timestamp":1561532003000},"page":"2267-2273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Quality of life in children with severe forms of idiopathic nephrotic syndrome in stable remission\u2014A cross\u2010sectional study"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9943-2860","authenticated-orcid":false,"given":"Aphaia","family":"Roussel","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie et Dialyse P\u00e9diatrique H\u00f4pital Trousseau, APHP.6, and DHU i2b Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Daniel","family":"Delbet","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Dialyse P\u00e9diatrique H\u00f4pital Trousseau, APHP.6, and DHU i2b Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurianne","family":"Micheland","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, ECSTRA H\u00f4pital Saint\u2010Louis, AP\u2010HP Paris 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