{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:51:51Z","timestamp":1790790711840,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the regional cerebral tissue oxygenation saturation (rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub>) in a group of infants requiring less invasive surfactant administration (<jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>) as compared to infants with continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In preterm infants with a gestational age 26 0\/7\u201031 6\/7\u00a0weeks, we conducted an observational study using near\u2010infrared spectroscopy (<jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content>) in the first 120\u00a0hours of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed the data of 22 infants who never received surfactant (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>), 22 infants had <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>) and 6 infants received surfactant via endotracheal tube (<jats:styled-content style=\"fixed-case\">ETT<\/jats:styled-content>). Four infants had both surfactant application modes including six <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> applications. In total, there were 32 successful <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> applications but 44 attempts; 13\/44 (30%) of <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> attempts resulted in a 20% decrease of rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub>. During the first 120\u00a0hours of life, rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> values of <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> were similar to those of infants in the <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> group, that is median rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> values 90% vs 85%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.126). Episodes with rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> values &lt;65% were 0.4% in the <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> group as compared to 4.8% in the <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our observational data indicate that rc<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>2<\/jats:sub> values of infants in the <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> group were similar to the <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14939","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T16:39:22Z","timestamp":1563295162000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants"],"prefix":"10.1111","volume":"109","author":[{"given":"Kathrin","family":"Hanke","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja K.","family":"Rausch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Institute for Medical Biometry and Statistics University of L\u00fcbeck L\u00fcbeck 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