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Weight gain was reported as an adverse reaction in 33%, but an increase in standardised body mass index, adjusted for age and sex (BMI <jats:italic>z<\/jats:italic>\u2010score), was detected in 75% of patients with sufficient data. The statistically significant median changes during the study were an increase of 0.46 in BMI <jats:italic>z<\/jats:italic>\u2010score, a reduction of 0.25\u00a0mmol\/L in fasting plasma high\u2010density lipoprotein and an increase of 0.28\u00a0mmol\/L in triglyceride values. The weight gain was most apparent in patients treated with just an SGA or SGA plus melatonin. Patients treated with an SGA plus medication for attention deficit hyperactivity disorder were less likely to gain weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SGA\u2010induced metabolic disturbances remained partly unrecognised in children under 13\u00a0years of age and more systematic monitoring is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14951","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T06:18:06Z","timestamp":1564467486000},"page":"342-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Current follow\u2010up practices often fail to detect metabolic and neurological adverse reactions in children treated with second\u2010generation 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