{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T02:23:10Z","timestamp":1773627790501,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of our review was to describe the clinical response to inhaled nitric oxide (iNO) in a series of preterm babies in respiratory failure during uplift transfers to a neonatal intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of critical newborns with gestational age &lt;34<jats:sup>+0<\/jats:sup>\u00a0weeks transferred from January 2013 to December 2018. Data were extracted from our Clinical Information System for transport. The primary measure of this review was to assess whether a significant improvement in the oxygenation saturation index (OSI) occurred following the use of iNO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty preterm babies &lt;34<jats:sup>+0<\/jats:sup>\u00a0weeks were included in our review. OSI, as a measure of oxygenation, did not statistically improve as an immediate response to iNO from referral to receiving hospital (17.1 vs 16.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.7). We found that pH (7.15 vs 7.29; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) and pCO2 (8.1 vs 6.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05) significantly improved probably based on ventilation management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following the recommendations of the American Academy of Paediatrics and other organizations, iNO should not routinely be used during the neonatal transfer of preterm babies &lt;34<jats:sup>+0<\/jats:sup> in respiratory failure. We need to conduct further studies to establish which selected preterm patients would benefit from being treated with iNO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14958","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T11:43:09Z","timestamp":1564746189000},"page":"309-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The immediate efficacy of inhaled nitric oxide treatment in preterm infants with acute respiratory failure during neonatal transport"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-0667","authenticated-orcid":false,"given":"Felipe","family":"Garrido","sequence":"first","affiliation":[{"name":"Connect NW, St. Mary's Hospital, Newborn Intensive Care Services  Manchester University NHS Foundation Trust Manchester UK"},{"name":"Newborn Intensive Care Unit Cl\u00ednica Universidad de Navarra Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-5038","authenticated-orcid":false,"given":"Juan Luis","family":"Gonzalez\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operative Research, Facultad de Medicina University of C\u00e1diz C\u00e1diz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Lomax","sequence":"additional","affiliation":[{"name":"Connect NW, St. Mary's Hospital, Newborn Intensive Care Services  Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Dady","sequence":"additional","affiliation":[{"name":"Connect NW, St. Mary's Hospital, Newborn Intensive Care Services  Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"356","article-title":"Inhaled nitric oxide therapy for pulmonary disorders of the term and preterm infant","volume":"40","author":"Huo Y","year":"2017","journal-title":"Semin Perinatol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2725"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3444"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6010004"},{"key":"e_1_2_8_6_1","first-page":"CD000509","article-title":"Inhaled nitric oxide for respiratory failure in preterm infants (Review)","volume":"1","author":"Barrington KJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199711)24:5<319::AID-PPUL3>3.0.CO;2-D"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.08.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031154"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.050"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.3.325"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369774"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181b0653d"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3290"},{"key":"e_1_2_8_16_1","unstructured":"INOmax [Internet]. 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