{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:42:03Z","timestamp":1793497323542,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study estimated the diagnostic yield of oesophagogastroduodenoscopy (OGD) in young children with non\u2010acute, non\u2010specific gastrointestinal or respiratory symptoms who were treated by a Finnish tertiary level referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart analysis was performed on 1850 Finnish children under 7\u00a0years of age who underwent their first diagnostic OGDs at Helsinki University Hospital during 2006\u20102016. We noted the endoscopy indications, macroscopic findings, the histology of the mucosal biopsies and the follow\u2010up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the exclusion criteria were applied, we enrolled 666 patients (57.7% boys) at a median age of 3.5\u00a0years. The number of children with non\u2010specific symptoms referred for OGD increased 2.3\u2010fold in 11\u00a0years. A routine set of biopsies was obtained in 644\/666 (96.7%) of the endoscopies. The OGD was both macroscopically and histologically normal in 519\/644 (80.6%) of cases. The most common indication was to rule out gastro\u2010oesophageal reflux disease in 268\/666 (40.2%) cases, and the most frequent histological diagnosis was mild to moderate oesophagitis in 57\/644 (8.9%) cases. There was no erosive oesophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic yield of macroscopic and histological OGD findings was low in our cohort. Unless there are alarming symptoms, younger children do not need OGD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15027","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T08:51:30Z","timestamp":1568969490000},"page":"827-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upper endoscopy for non\u2010acute non\u2010specific symptoms is seldom beneficial for children under the age of seven"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-7297","authenticated-orcid":false,"given":"Noora","family":"Helin","sequence":"first","affiliation":[{"name":"Department of Paediatrics Children\u2019s Hospital Paediatric Research Centre University of Helsinki Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-8415","authenticated-orcid":false,"given":"Kaija\u2010Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Tampere University Hospital University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Rintala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Paediatric Research Centre Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Merras\u2010Salmio","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Children\u2019s Hospital Paediatric Research Centre University of Helsinki Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-18-24"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922814528034"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001864"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.2.150"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0421"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081671"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41893.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i21.3915"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2017.01.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-0673.2004.01832.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16150"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i28.8508"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182478f83"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810392773"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"1","article-title":"Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? 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