{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:42:35Z","timestamp":1774572155113,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T00:00:00Z","timestamp":1569628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Histological chorioamnionitis (HCA) is associated with preterm birth and adverse neonatal outcomes. We evaluated the rise in C\u2010reactive protein (CRP) in preterm infants as a predictor of HCA severity and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive preterm infants, born January 2009 to January 2014 in the National Maternity Hospital, Dublin, under 32\u00a0weeks' gestation or &lt;1.5\u00a0kg birthweight, were included. Histological chorioamnionitis was staged as maternal inflammatory response, foetal inflammatory response and non\u2010HCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm infants (n\u00a0=\u00a0518) were included with a mean gestational age 28.5\u00a0\u00b1\u00a02.8\u00a0weeks, birthweight 1.1\u00a0\u00b1\u00a00.3\u00a0kg, and 53.5% were male. Histological chorioamnionitis was found in 25.4%. Histological chorioamnionitis was present in 93.7% when CRP\u00a0&gt;\u00a05\u00a0mg\/L, 65.2% when CRP 1\u20105\u00a0mg\/L and in 19.4% when CRP\u00a0&lt;\u00a01\u00a0mg\/L. When both the immature to total neutrophil (IT) ratio was &gt;0.2 and the CRP\u00a0&gt;\u00a01\u00a0mg\/L the positive predictive value and negative predictive value for HCA were 92.5% and 84.9%, respectively. Histological chorioamnionitis was associated with more resuscitation and respiratory distress syndrome (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). A CRP\u00a0&gt;\u00a010\u00a0mg\/L was associated with a foetal inflammatory response and increased early\u2010onset sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher early CRP was a surrogate predictor of HCA and correlated with the severity of HCA. Higher CRP and HCA were associated with adverse early outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15038","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T22:15:13Z","timestamp":1569708913000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Histological chorioamnionitis is predicted by early infant C\u2010reactive protein in preterm infants and correlates with neonatal outcomes"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-5115","authenticated-orcid":false,"given":"Emer","family":"Ryan","sequence":"first","affiliation":[{"name":"Paediatrics Trinity College Dublin The University of Dublin Dublin Ireland"},{"name":"Neonatology National Maternity Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doireann","family":"Eves","sequence":"additional","affiliation":[{"name":"Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poornima Jayadev","family":"Menon","sequence":"additional","affiliation":[{"name":"Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Alnafisee","sequence":"additional","affiliation":[{"name":"Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoghan E.","family":"Mooney","sequence":"additional","affiliation":[{"name":"Pathology National Maternity Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Downey","sequence":"additional","affiliation":[{"name":"Pathology National Maternity Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Culliton","sequence":"additional","affiliation":[{"name":"Laboratory Medicine National Maternity Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F. 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