{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:13:57Z","timestamp":1792109637159,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy's and St Thomas' NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000656","name":"Menzies Centre for Australian Studies, King's College London, University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonates frequently require supplementary oxygen but may develop complications if the oxygen saturation is outside the target range. This review aimed to determine whether the algorithms used in closed loop automated oxygen control systems influenced their efficacy and whether use of the systems reduced relevant, long\u2010term neonatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted using PubMed and Google Scholar. The search terms were \u2018closed loop\u2019 or \u2018automat*\u2019, \u2018oxygen\u2019 and \u2018neonat*\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies were identified: sixteen comparison clinical studies, an observational study and an animal study. Overall, closed loop automated oxygen control was associated with an increased percentage of time spent within the target oxygen saturation range and there were fewer manual adjustments to the inspired oxygen concentration when compared with manual oxygen control. The systems were effective in infants on non\u2010invasive respiratory support or mechanically ventilated, but no study included term\u2010born infants. No long\u2010term data were available to determine if complications of oxygen toxicity were reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Closed loop automated oxygen control has been shown in short term trials including preterm and low birth weight infants to improve target saturation achievement. Whether long\u2010term outcomes will be improved with their use requires investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15089","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T20:54:05Z","timestamp":1573592045000},"page":"914-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Closed loop automated oxygen control in neonates\u2014A review"],"prefix":"10.1111","volume":"109","author":[{"given":"Sarah","family":"Sturrock","sequence":"first","affiliation":[{"name":"Women and Children\u2019s Health School of Life Course Sciences Faculty of Life Sciences and Medicine King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Williams","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health School of Life Course Sciences Faculty of Life Sciences and Medicine King\u2019s College London 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