{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:43:57Z","timestamp":1779338637030,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the effectiveness and safety of rapid and slow rehydration in children aged 6\u201060\u00a0months with dehydrating diarrhoea and severe malnutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled trial was conducted from July 2011 to March 2014 at the International Centre for Diarrhoeal Disease Research Bangladesh. We included children with weight for age and, or, weight for length <jats:italic>Z<\/jats:italic>\u2010scores of less than \u22123 or with bipedal oedema and acute diarrhoea with severe dehydration. The children received intravenous fluid at different rates: 105 rapidly over six hours and 103 slowly over the 12\u00a0hours recommended by the World Health Organization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the children were successfully rehydrated. The admittance weights were similar for the slow and rapid groups: 8.4\u00a0kg and 8.3\u00a0kg. After 24\u00a0hours, the mean percentage weight gain was 8.5% and 9.0%, respectively. This confirmed that most of the children had been suffering from severe dehydration on admission. The respective proportions of children who received unscheduled intravenous fluid were 18% and 17%. None developed fluid overload or heart failure and most recovered normal renal function after rehydration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rapid rehydration saved time, was as safe as slow rehydration and was a better option for dehydrating diarrhoea and severe malnutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15134","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T08:04:18Z","timestamp":1576137858000},"page":"1473-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Randomised trial showed that rapid rehydration of severely malnourished children with dehydrating diarrhoea was as safe and effective as slow rehydration"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-9033","authenticated-orcid":false,"given":"Nur H.","family":"Alam","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Ashraf","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishat","family":"Jahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklaus","family":"Gyr","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00120-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60937-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.1.193"},{"key":"e_1_2_11_5_1","first-page":"1207","article-title":"Malnutrition is an underlying cause of childhood deaths associated with infectious diseases in developing countries","volume":"78","author":"Rice AL","year":"2000","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_6_1","first-page":"223","article-title":"Why have mortality rates for severe malnutrition remained so high?","volume":"74","author":"Schofield C","year":"1996","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_7_1","volume-title":"Management of severe malnutrition: a manual for physicians and other senior health workers","author":"World Health Organization","year":"1999"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07499-6"},{"key":"e_1_2_11_9_1","first-page":"365","article-title":"Chemical composition of the whole body and individual tissues of two Jamaican children whose death resulted primarily from malnutrition","volume":"33","author":"Halliday D","year":"1967","journal-title":"Clin Sci"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.26.127.205"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19700021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612183152506"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318180af27"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200305030-00002"},{"key":"e_1_2_11_15_1","volume-title":"Acute respiratory infections in children: Case management in small hospitals in developing countries. 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