{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:26:40Z","timestamp":1772537200535,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the characteristics of infants with neonatal encephalopathy (NE) receiving therapeutic hypothermia (TH) who developed late onset oxygen requirement during or after rewarming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants were stratified by receiving (a) new onset isolated oxygen requirements during or after rewarming; (b) no respiratory support during hospital stay; and (c) invasive and\/or non\u2010invasive respiratory support before or during cooling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 136 infants treated with TH, 49 (36%) did not require any respiratory support, and 78 (57.4%) received invasive or non\u2010invasive support before or during cooling. Nine infants (6.6%) developed late onset oxygen requirement<jats:bold>.<\/jats:bold> The late onset oxygen requirement started at median age of 3.8\u00a0days (IQR 3.6\u20105.2) and ended at median 7.5\u00a0days (IQR 5.8\u201012.7). Total hours of O<jats:sub>2<\/jats:sub> exposure were median 62.0 (IQR 24.4\u2010112.6). Maximum support was low\u2010flow nasal cannula from 100% oxygen source with a flow rate of 40\u2010250\u00a0mL\/min. Infants in this group had higher Apgar scores, milder metabolic acidosis and no seizures. Three infants had diagnostic investigations without significant findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A small percentage of neonates with NE developed late onset oxygen requirement during or after rewarming<jats:bold>.<\/jats:bold> Late oxygen requirement was associated with evidence of less severe perinatal hypoxia\u2010ischaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15222","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T13:14:50Z","timestamp":1581426890000},"page":"2258-2265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Late onset oxygen requirement following neonatal therapeutic hypothermia"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-7407","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Dib","sequence":"first","affiliation":[{"name":"Department of 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