{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:42:24Z","timestamp":1747183344714,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Due to reduced PaO<jats:sub>2<\/jats:sub>, aircrafts at cruising altitudes are pressurised to a cabin altitude of 2438\u00a0m, equivalent to breathing FiO<jats:sub>2<\/jats:sub> 0.15. Portable oxygen concentrators (POCs) are approved for onboard oxygen supply with lack of evidence, especially in infants. We assessed POCs (continuous\u2010flow cPOC vs. pulsed\u2010flow pPOC) under simulated altitude conditions performing Hypoxic Challenge Testing (HCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomised controlled crossover trial, we included patients &lt;1\u00a0year born prematurely. In incidents of hypoxia (SpO<jats:sub>2<\/jats:sub>\u00a0\u2264\u00a085%), oxygen was administered through POC. In patients with a positive hypoxia reversal, HCT was repeated 24\u00a0hours later. If hypoxia occurred during the second testing, oxygen was given using the alternative POC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We randomised 26 patients; 22 patients received allocated intervention (4 dropped out). Mean gestational age 30.4\u00a0weeks, mean corrected age 38.2\u00a0weeks. Both POCs achieved immediate hypoxia reversal in all cases (SpO<jats:sub>2<\/jats:sub> cPOC\/pPOC 98%\/99.4% (95%CI \u22122.91, 0.01)) without any adverse events. No significant difference was observed in patients with BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both POCs generated sufficient oxygen to reverse HCT induced hypoxia. Although pPOCs are not recommended in paediatric age, our data suggest their effectiveness even in neonates without any associated adverse events. Future research on pPOCs safety is required to establish recommendations for their use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15242","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T09:29:36Z","timestamp":1583227776000},"page":"2287-2291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of portable oxygen concentrators in infants undergoing hypoxic challenge testing. 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