{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:29Z","timestamp":1787013869976,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012921","name":"Royal College of Surgeons in Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained in global hypoxia\u2010ischaemia. In addition, troponin is a sensitive marker of severity of stroke in adults and neonatal encephalopathy (NE). We aimed to examine the relationship between troponin T in infants with perinatal asphyxia and brain injury on MRI and correlate with neurodevelopmental outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum troponin was sampled in infants requiring resuscitation at birth and\/or neonatal encephalopathy in a tertiary referral neonatal centre. Birth history, clinical parameters, neuroimaging and developmental outcome (Bayley Scores of Infant Development [BSID] III) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infants with perinatal asphyxia (n\u00a0=\u00a054) had serum troponin T measured and 27 required therapeutic hypothermia. Troponin T levels on days 1 and 2 were predictive of need for TH, development of seizures and grade II\/III NE (AUC\u00a0=\u00a00.7;\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values\u00a0&lt;\u00a0.001), troponin T levels on days 1, 2 and 3 were highly significant predictors of mortality (AUC\u00a0=\u00a00.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values .005). The cut\u2010off values of troponin T for best prediction of mortality were 0.84, 0.63 and 0.58\u00a0ng\/mL on days 1, 2 and 3, respectively. Troponin T on day 3 of life was predictive of injury in the combined area of basal ganglia\/watershed on MRI (AUC 0.70;\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infants with brain injury on neuroimaging following perinatal asphyxia had significantly elevated serum troponin, and troponin also correlated with developmental scores at 2\u00a0years. Further studies combining troponin and MRI may assist in the classification of neonatal brain injury to define aetiology, prognosis and response to treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.15255","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T08:04:33Z","timestamp":1586765073000},"page":"2266-2270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Troponin T correlates with MRI results in neonatal encephalopathy"],"prefix":"10.1111","volume":"109","author":[{"given":"Deirdre U.","family":"Sweetman","sequence":"first","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"National Children\u2019s Research Centre Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1143","authenticated-orcid":false,"given":"Lynne","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Trinity College Dublin Children\u2019s Health Ireland in Tallaght &amp; Trinity Translational Medicine Institute St James Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hurley","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Trinity College Dublin Children\u2019s Health Ireland in Tallaght &amp; Trinity Translational Medicine Institute St James Hospital Dublin Ireland"},{"name":"Coombe Women\u2019s and infant\u2019s University Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chike","family":"Onwuneme","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. William Gordon","family":"Watson","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F. A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-5925","authenticated-orcid":false,"given":"Marie","family":"Slevin","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Donoghue","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6798-2158","authenticated-orcid":false,"given":"Eleanor J.","family":"Molloy","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"National Children\u2019s Research Centre Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"Department of Paediatrics Trinity College Dublin Children\u2019s Health Ireland in Tallaght &amp; Trinity Translational Medicine Institute St James Hospital Dublin Ireland"},{"name":"Coombe Women\u2019s and infant\u2019s University Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0169-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.09.026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.042"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00142"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013999"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00104.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08035250510041222"},{"key":"e_1_2_8_12_1","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich AJ","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13745"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13555"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2190"},{"key":"e_1_2_8_17_1","volume-title":"Bayley scales of infant and toddler development","author":"Bayley N","year":"2006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.06.014"},{"key":"e_1_2_8_20_1","first-page":"223","article-title":"Four patterns of perinatal brain damage and their conditions of occurrence in primates","volume":"10","author":"Myers RE","year":"1975","journal-title":"Adv Neurol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.185967"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.133140"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.1"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.15255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.15255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:16:20Z","timestamp":1693858580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.15255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/apa.15255"],"URL":"https:\/\/doi.org\/10.1111\/apa.15255","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,13]]},"assertion":[{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}