{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:36:27Z","timestamp":1771259787039,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed the diagnostic accuracy of serum (1\u00a0\u2192\u00a03)\u2010\u03b2\u2010D\u2010glucan (BDG) for neonatal invasive candidiasis (NIC) using the recommended cut\u2010off usually used in adults for detecting invasive candidiasis and searched for an optimal cut\u2010off for ruling out NIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cross\u2010sectional study at Nantes University medical centre from January 2017 to July 2018. All consecutive newborn infants of less than 28\u00a0days of corrected age, with clinically suspected NIC, who underwent BDG assay, were included. Sensitivity and specificity were calculated by using the recommended cut\u2010off of 80\u00a0pg\/mL. Receiver operating characteristic curve analysis was used to identify an optimal cut\u2010off value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 55 newborn infants with 61 episodes of suspected NIC. Their median gestational and chronological ages were 28.0\u00a0weeks (interquartile range [IQR] 26.4\u201034.1) and 10.0\u00a0days (IQR 6.0\u201022.0), respectively. Of 61 episodes, seven revealed NIC. Sensitivity and specificity were 85.7% (95% confidence interval [CI] 42.1%\u201099.6%) and 51.9% (37.8%\u201065.7%) with the recommended cut\u2010off, respectively. An optimal cut\u2010off of 174\u00a0pg\/mL offered the same sensitivity but higher specificity 77.8% (64.4%\u201088.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recommended cut\u2010off of 80\u00a0pg\/mL was probably too low for ruling out NIC. A higher cut\u2010off might have been more appropriate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15321","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T18:50:13Z","timestamp":1587235813000},"page":"79-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum (1\u00a0\u2192\u00a03)\u2010\u03b2\u2010D\u2010glucan could be useful to rule out invasive candidiasis in neonates with an adapted cut\u2010off"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-9931","authenticated-orcid":false,"given":"Pauline","family":"Cliquennois","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit University Hospital of Nantes Nantes 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