{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:09:59Z","timestamp":1793315399018,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Multidrug\u2010resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device\u2010associated infections, especially those involving multidrug\u2010resistant bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective, observational study. Children aged \u22651\u00a0month and &lt;18\u00a0years admitted to the paediatric intensive care unit from 2008 to 2017, with a device\u2010associated infection microbiologically confirmed were included. Patients infected with resistant bacteria were compared with those who had a drug\u2010susceptible infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 213 patients. Out of all the device\u2010associated infections, 22% (48 patients) were caused by multidrug\u2010resistant bacteria. The most frequent were extended\u2010spectrum beta\u2010lactamase (ESBL)\u2010producing enterobacteria. Cardiovascular diseases, age under 1year, comorbidity, prolonged use of invasive device, and length of stay until infection were risk factors for resistant bacteria, but not specifically for ESBL\u2010producing bacteria. Length of stay and mortality was increased in patients with multidrug\u2010resistant bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Being under 1\u2010year\u2010old and having a cardiovascular disease were the two major risk factors for resistant bacterial infection. ESBL\u2010producing bacteria were the most frequent multidrug\u2010resistant agents. However, patients with ESBL\u2010producing bacteria did not have any additional risk factors, so they may have been colonised in the community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15342","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:24:46Z","timestamp":1588915486000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Device\u2010associated multidrug\u2010resistant bacteria surveillance in critically ill children: 10\u00a0years of experience"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7481","authenticated-orcid":false,"given":"M\u00f2nica","family":"Girona\u2010Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fres\u00e1n","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garcia\u2010Garcia","sequence":"additional","affiliation":[{"name":"Immunology Department Hospital Sant Joan de D\u00e9u\u2010Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-2995","authenticated-orcid":false,"given":"Sara","family":"Bobillo\u2010Perez","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-116X","authenticated-orcid":false,"given":"Monica","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Felipe","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Esther","family":"Esteban","sequence":"additional","affiliation":[{"name":"Zoology and Anthropology Section Department of Evolutionary Biology, Ecology and Environmental Sciences Faculty of Biology GREAB\u2010 Biological Anthropology Research Group Institut de Recerca de la Biodiversitat (IRBio) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-4425","authenticated-orcid":false,"given":"Iolanda","family":"Jordan","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Institut de Recerca Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group Institut de Recerca Hospital Sant Joan de D\u00e9u, Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Paediatric Intensive Care Unit CIBERESP, Hospital Sant Joan de D\u00e9u\u2010Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"383","article-title":"Antimicrobial resistance. 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