{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:14:05Z","timestamp":1770268445606,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study in CDH children (\u22657\u00a0years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise) and Pediatric Quality of Life Inventory questionnaires (PedsQoL 4.0) were collected. Data of OA children were previously published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four CDH patients (male: 53%, median age: 11\u00a0years, IQR 9\u201014) were compared to 54 OA patients (male: 61%, median age: 13\u00a0years, IQR: 11\u201015). CDH children had significantly more frequent history of pneumonia (30% vs 13%), exercise limitation (54% vs 35%) and chest deformity (39% vs 11%); 46% had an obstructive pattern and 66% an abnormal cardiopulmonary exercise test. The median PedsQoL total score in children was 81 (IQR 73\u201090) in CDH and 81 (IQR 72\u201091) in OA (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.8). In CDH, duration of neonatal oxygen therapy, hospitalisation for respiratory disease, exercise limitation, inhaled corticosteroids treatment, chest deformity, abnormal cardiopulmonary exercise test and lower forced expiratory volume in one second were significantly associated with lower QoL scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PedsQoL scores remained satisfactory in CDH children with CDH, with no difference compared to OA. Patients with respiratory morbidity and lung function impairment, who displayed lower scores, should be identified in order to optimise their management in reference centres.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15426","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T01:18:35Z","timestamp":1592788715000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity"],"prefix":"10.1111","volume":"110","author":[{"given":"Laura","family":"Darmaun","sequence":"first","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit Univ. Lille, CHU Lille H\u00f4pital Jeanne de Flandre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-2113","authenticated-orcid":false,"given":"Stephanie","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit Univ. Lille, CHU Lille H\u00f4pital Jeanne de Flandre Lille France"},{"name":"Univ. Lille, CHU Lille Reference Centre for Rare Oesophageal Diseases U995 \u2010 LIRIC \u2010 Lille Inflammation Research International Centre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Drumez","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille ULR 2694 \u2010 METRICS: \u00c9valuation des technologies de sant\u00e9 et des pratiques m\u00e9dicales Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Mur","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"de Langle\u2010Chevalier","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit Univ. Lille, CHU Lille H\u00f4pital Jeanne de Flandre Lille France"},{"name":"CHU Lille Reference Centre for Rare Disease Congenital diaphragmatic hernia H\u00f4pital Jeanne de Flandre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"N\u00e8ve","sequence":"additional","affiliation":[{"name":"CHU Lille Univ. Lille UR 4483 Service des Explorations Fonctionnelles Respiratoires Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Michaud","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille Reference Centre for Rare Oesophageal Diseases U995 \u2010 LIRIC \u2010 Lille Inflammation Research International Centre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille Reference Centre for Rare Oesophageal Diseases U995 \u2010 LIRIC \u2010 Lille Inflammation Research International Centre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Thumerelle","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit Univ. Lille, CHU Lille H\u00f4pital Jeanne de Flandre Lille France"},{"name":"Univ. Lille, CHU Lille Reference Centre for Rare Oesophageal Diseases U995 \u2010 LIRIC \u2010 Lille Inflammation Research International Centre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-7221","authenticated-orcid":false,"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit Univ. 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