{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:27:16Z","timestamp":1791930436919,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop a fast bedside test for prediction and early targeted intervention of bronchopulmonary dysplasia (BPD) to improve the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicentre study of preterm infants with gestational age 24\u201031\u00a0weeks, clinical data present at birth were combined with spectral data of gastric aspirate samples taken at birth and analysed using artificial intelligence. The study was designed to develop an algorithm to predict development of BPD. The BPD definition used was the consensus definition of the US National Institutes of Health: Requirement of supplemental oxygen for at least 28\u00a0days with subsequent assessment at 36\u00a0weeks postmenstrual age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six (43%) of the 61 included infants developed BPD. Spectral data analysis of the gastric aspirates identified the most important wave numbers for classification and surfactant treatment, and birth weight and gestational age were the most important predictive clinical data. By combining these data, the resulting algorithm for early diagnosis of BPD had a sensitivity of 88% and a specificity of 91%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A point\u2010of\u2010care test to predict subsequent development of BPD at birth has been developed using a new software algorithm allowing early targeted intervention of BPD which could improve the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15438","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T19:15:01Z","timestamp":1592853301000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Bronchopulmonary dysplasia predicted at birth by artificial intelligence"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-9394","authenticated-orcid":false,"given":"Henrik","family":"Verder","sequence":"first","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiring","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology LAC+USC Medical Center &amp; PH Good Samaritan Hospital Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Scoutaris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Povl","family":"Verder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben E.","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnar","family":"H\u00f6skuldsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aalborg Hospital University of Aalborg Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Odense Hospital University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Eschen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Fenger\u2010Gr\u00f8n","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kolding Hospital University of Southern Denmark Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes","family":"Reinholdt","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Smedegaard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schousboe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Holbaek University Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00190-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00510"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14896"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14831"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00397"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448985"},{"key":"e_1_2_10_8_1","first-page":"CD001456","article-title":"Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome","volume":"11","author":"Bahadue FL","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"1051","key":"e_1_2_10_9_1","first-page":"9","article-title":"Surfactant therapy and nasal continuous positive airway pressure for newborns with respiratory distress syndrome","volume":"331","author":"Verder H","year":"1994","journal-title":"N Engl J Med"},{"key":"e_1_2_10_10_1","first-page":"1571","article-title":"Lung function in premature infants can be improved. 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