{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:30:49Z","timestamp":1772555449526,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hypertransaminasaemia is a common incidental finding in children. It has been demonstrated that even prolonged elevation usually resolves spontaneously without clear aetiology. The aim of this study was to evaluate whether a longer follow\u2010up period, on a larger group, supports the previous findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical charts of children diagnosed with prolonged idiopathic hypertransaminasaemia, which spontaneously resolved over the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 468 patients screened for elevated transaminases levels, 87 patients younger than 5\u00a0years of age were included in the study. An aetiology was found in half of the patients, and the most common aetiologies were fatty liver and cytomegalovirus (CMV) infection.<\/jats:p><jats:p>Aminotransferase abnormality persisted for a median of 10\u00a0months, and alanine aminotransferase (ALT) levels ranged from 1.5 to 15.9\u2010fold of the upper limit of normal (ULN).<\/jats:p><jats:p>After normalisation of transaminase levels, the values remained normal for a documented mean period of 6.4\u00a0\u00b1\u00a03.0\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although idiopathic asymptomatic aminotransferase elevation in healthy children resolves spontaneously in most children, the abnormality may be prolonged. Comprehensive workup finds aetiology only in half of the patients, and the most common aetiologies are fatty liver and CMV hepatitis, which can be diagnosed by non\u2010invasive methods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15446","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T20:40:27Z","timestamp":1593117627000},"page":"668-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prolonged abnormal isolated aminotransferase levels in healthy children is a benign condition"],"prefix":"10.1111","volume":"110","author":[{"given":"Ramit","family":"Magen\u2010Rimon","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology &amp; Nutrition institute Faculty of Medicine Ruth Children's Hospital of Haifa Rambam Medical Center Technion Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Shaoul","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology &amp; Nutrition institute Faculty of Medicine Ruth Children's Hospital of Haifa Rambam Medical Center Technion Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.20-11-376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421707"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133715"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.517"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311935"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000447"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.02.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.121194"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00416-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36061"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(01)90074-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1635-7"},{"issue":"8","key":"e_1_2_8_14_1","first-page":"722","article-title":"Diagnosis of hyper transaminasemia in childhood","volume":"86","author":"Bouyahia O","year":"2008","journal-title":"Tunis Med"},{"issue":"5","key":"e_1_2_8_15_1","first-page":"535","article-title":"Differential diagnosis of elevated transaminases","volume":"8","author":"Lacaille F","year":"2001","journal-title":"Arch Pediatr"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13176"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.15446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.15446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:27:33Z","timestamp":1693736853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.15446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/apa.15446"],"URL":"https:\/\/doi.org\/10.1111\/apa.15446","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]},"assertion":[{"value":"2020-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}