{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:30:11Z","timestamp":1785465011441,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Necrotising enterocolitis (NEC) is a disease associated with high mortality and morbidity, low birthweight and prematurity are risk factors. This study reports outcomes of babies having emergency laparotomy for NEC, examining institutional trends and exploring impact of multiple variables on mortality at 30\u00a0days and 1\u00a0year post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case records of babies with ICD coding for NEC were examined from 2000 to 2015. After exclusions, 243 cases were identified\u2014confirmed by operative findings and histology. Cohort demographics and trends in mortality were investigated, and the relationship of common variables to mortality was modelled with univariate and multivariate logistic regression to generate a mortality prediction tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean gestational age was 28\u00a0+\u00a04\u00a0weeks. A 30\u2010day mortality was 18.9%. Gestation, birthweight and area of bowel affected were significant of outcome (mortality), and the presence of pre\u2010operative pneumoperitoneum was strongly correlated. Year of surgery and congenital cardiac pathology requiring intervention were not significant. Using multivariate regression modelling, a mortality outcome prediction tool has been developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Good survival following operation for NEC (&gt;70%) is feasible, even in those babies born extremely premature (&lt;28\u00a0weeks) and post\u2010operatively re\u2010located to tertiary NICUs. With increasing gestational age (&gt;32\u00a0weeks), mortality is uncommon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15510","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T20:29:06Z","timestamp":1596400146000},"page":"495-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Necrotising enterocolitis\u2013A 15\u2010year outcome report from a UK specialist centre"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-8738","authenticated-orcid":false,"given":"William","family":"Calvert","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery Alder Hey Children\u2019s NHS Foundation Trust Liverpool UK"},{"name":"University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthika","family":"Sampat","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery 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