{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:57:55Z","timestamp":1790398675786,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Anti\u2010tumour necrosis factor (TNF)\u2010\u03b1 drugs are effective treatments for the management of moderate\/severe Crohn's disease (CD), but treatment failure is common. In the treatment of paediatric CD, there are no data about the use of a third introduced subcutaneous TNF antibody golimumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the efficacy of golimumab for adolescents with moderate\/severe CD. Retrospective analyses were done in all 7 (5 girls) adolescents who received golimumab at a median age of 17\u00a0years for a median of 7.2\u00a0months. Paediatric Crohn's disease activity index (PCDAI), full blood count, inflammatory markers, use of corticosteroids and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With golimumab, 5 of the 7 children were PCDAI responders and 2 entered remission (PCDAI &lt;10). Faecal calprotectin was significantly reduced after 4\u00a0weeks compared to baseline. Out of five children, steroid withdrawal was possible in one and steroid reduction in two cases. There were no serious side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In moderate\/severe CD, golimumab induced clinical remission with PCDAI response. Golimumab may be an effective rescue therapy in refractory CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.15522","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T23:45:18Z","timestamp":1597189518000},"page":"661-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Golimumab in adolescents with Crohn's disease refractory to previous tumour necrosis factor antibody"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-5094","authenticated-orcid":false,"given":"Judith","family":"Pichler","sequence":"first","affiliation":[{"name":"Department of Paediatric Nephrology and Gastroenterology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Memaran","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology and Gastroenterology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf Dietrich","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology and Gastroenterology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Aufricht","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology and Gastroenterology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bidmon\u2010Fliegenschnee","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology and Gastroenterology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"57","article-title":"Infliximab therapy in pediatric Crohn's disease: a review","volume":"3","author":"Parashette KR","year":"2010","journal-title":"Clin Exp Gastroenterol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.7.939"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.18144"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00777.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.8.757"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00956.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20788"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20845"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102529"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.493"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.046"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.12304"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203435"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60506-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24638"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.048"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.06.010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(12)63121-7"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001262"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000480202.44901.14"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1353"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001258"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000163736.30261.82"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091339"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_2_11_27_1","unstructured":"WHO Child growth standards:WHO growth software:http:\/\/www.who.int\/growthref\/tools\/who_anthroplus_manual.pdf?ua=1. 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