{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:51:43Z","timestamp":1773269503393,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to compare the performances of the World Health Organization (WHO) and population\u2010based (PB) references in the screening for hydrocephalus in infants aged &lt;2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected 341 longitudinal head circumference (HC) measurements of hydrocephalic infants and 120\u00a0181 measurements of 15\u00a0145 healthy infants from primary care. The measurements were converted into z\u2010scores, and a new screening parameter, change in HC standard deviation score (SDS) over time (\u0394HC SDS), was calculated. Comparisons were made using receiver operating characteristics analysis and linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean HC SDS<jats:sub>WHO<\/jats:sub>was 3.5 and the mean HC SDS<jats:sub>PB<\/jats:sub>was 2.9 in the hydrocephalic infants, and in healthy children, those numbers were 1.0 SDS<jats:sub>WHO<\/jats:sub>and 0 SDS<jats:sub>PB<\/jats:sub>, respectively. The best screening accuracy was obtained with the PB reference in combination with the \u0394HC SDS parameter (AUC 0.89). The accuracy of the WHO standard could be improved to a similar level by customising the screening cut\u2010offs of HC SDS according to the population and combining screening parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Auxology alone was not sufficient for the screening of hydrocephalus. The WHO standard should be validated in the population, and population\u2010specific cut\u2010offs for normality defined before its introduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15533","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T15:16:32Z","timestamp":1597418192000},"page":"881-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening of hydrocephalus in infants using either WHO or population\u2010based head circumference reference charts"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-4792","authenticated-orcid":false,"given":"Marjo","family":"Karvonen","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Eastern Finland Kuopio Finland"},{"name":"Department of Pediatrics Kuopio University Hospital Kuopio 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Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Helsinki University Central Hospital and Helsinki University Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Dunkel","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology William Harvey Research Institute Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Sankilampi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Eastern Finland Kuopio Finland"},{"name":"Department of Pediatrics Kuopio University Hospital Kuopio 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