{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:19:06Z","timestamp":1779164346875,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01ER0805"],"award-info":[{"award-number":["BMBF 01ER0805"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01ER1501"],"award-info":[{"award-number":["BMBF 01ER1501"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In animal studies, aminoglycosides induced ductus arteriosus relaxation in a dose\u2010dependent fashion. We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm infants (birthweight &lt;1000\u00a0grams or gestational age &lt;29\u00a0weeks) enrolled in 62 German neonatal intensive care units (NICUs) were analysed. NICUs were stratified according to the use of aminoglycosides as first\u2010line antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline data were not different when NICUs using aminoglycosides (n\u00a0=\u00a09965 infants) were compared to NICUs using other antibiotics (n\u00a0=\u00a01948 infants). Rates of surgical PDA closure were 5.9% for NICUs using aminoglycosides; 6.2% for units using gentamicin; and 5.0% for NICUs using tobramycin compared to 4.1% in NICUs using other antibiotics (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.140, respectively, Fisher's exact test). Indomethacin and ibuprofen use was more common in NICUs using aminoglycosides (41% vs 33%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, Fisher's exact test). Gentamicin trough levels were higher in NICUs with surgical closure rates above the mean (median 2.0\u00a0\u00b5g\/mL, inter\u2010quartile range 0.8\u20104.0\u00a0\u00b5g\/mL vs 1.2\u00a0\u00b5g\/mL, IQR 0.8\u20101.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, Mann\u2010Whitney <jats:italic>U<\/jats:italic> test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First\u2010line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15541","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T06:17:56Z","timestamp":1598595476000},"page":"826-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aminoglycosides were associated with higher rates of surgical patent ductus arteriosus closure in preterm infants"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-3508","authenticated-orcid":false,"given":"Janina","family":"Marissen","sequence":"first","affiliation":[{"name":"Department of Paediatrics University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Department University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"B\u00f6ckenholt","sequence":"additional","affiliation":[{"name":"Children's Hospital Amsterdamer Strasse  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Hoppenz","sequence":"additional","affiliation":[{"name":"Children's Hospital Amsterdamer Strasse  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja K.","family":"Rausch","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"},{"name":"Institute of Medical Biometry and Statistics University of Luebeck  Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"H\u00e4rtel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"},{"name":"Department of Paediatrics University of Wuerzburg  Wuerzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egbert","family":"Herting","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"G\u00f6pel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital of Schleswig\u2010Holstein University of Luebeck  Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the German Neonatal 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