{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:56:07Z","timestamp":1767920167723,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To establish the incidence and characteristics of paediatric thrombosis (PT) in a Canadian tertiary care centre during the era of low molecular weight heparin (LMWH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational case study of all patients &lt;18\u00a0years of age evaluated for arterial and venous thrombosis from May 2008 to July 2018 at McMaster Children\u2019s Hospital was conducted through the electronic medical record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of PT was 52.2 per 10\u00a0000 hospital admissions (n<jats:italic>\u00a0=\u00a0<\/jats:italic>477\/91\u00a0462). Provoked thrombosis was more prevalent (88.9%, n\u00a0=\u00a0424\/477) than unprovoked (2.9%, n\u00a0=\u00a014\/477) or idiopathic thrombosis (4%, n\u00a0=\u00a019\/477). Half of PT were in children &lt;2\u00a0years (51.2%, n\u00a0=\u00a0244\/477). Central vascular catheterisation was a contributory factor in more than half of thrombotic events (56.2%, n\u00a0=\u00a0268\/477), while trauma (1.1%, n\u00a0=\u00a05\/477), oral contraceptives (4%, n\u00a0=\u00a019\/477), infection (4%, n\u00a0=\u00a019\/477), surgery (6.9%, n\u00a0=\u00a033\/477) and malignancy (8.4%, n\u00a0=\u00a040\/477) were also risk factors. Arterial ischaemic stroke was diagnosed in 11.1% of cases (n\u00a0=\u00a053\/477), while pulmonary embolism was identified in 7.1% (n\u00a0=\u00a034\/477) and 1.7% of cases were fatal (n\u00a0=\u00a08\/477). LMWH was the first\u2010line therapeutic of choice (47.8%, n\u00a0=\u00a0228\/477), with 28.1% (n\u00a0=\u00a0134\/477) requiring no intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data reiterate the elevated thrombosis risk to which infants and children with central vascular access are exposed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15543","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T09:18:52Z","timestamp":1597915132000},"page":"1001-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central venous catheters are an important factor in paediatric thrombosis"],"prefix":"10.1111","volume":"110","author":[{"given":"Mouri","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Pediatrics McMaster Children\u2019s Hospital Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-6725","authenticated-orcid":false,"given":"Paul M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Nakrani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster Children\u2019s Hospital Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihir","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster Children\u2019s Hospital Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony K. 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