{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:35:45Z","timestamp":1791488145523,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure the prognostic value of C\u2010reactive protein (CRP) and its ability to predict pneumonia\u2010associated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 3.75\u2010years retrospective cohort analysis of all paediatric emergency department visits with a discharge diagnosis of pneumonia. Visits where CRP was not measured or with a discharge diagnosis of viral pneumonia were excluded. The following five outcomes were studied: hospitalisation, presence of parapneumonic effusion (PPE), placement of a chest drain, admission to paediatric intensive care unit (PICU) and bacteremia. A multivariate model was constructed and validated using <jats:italic>k<\/jats:italic>\u2010fold cross\u2010validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study time period, there were 2561 visits for pneumonia, of which 810 were included in our analysis. The median age of included children was 3.2\u00a0years (range 0.2\u201017.7). Overall, 38.8% visits ended in hospitalisation, 2.2% required admission to PICU, 15.2% were complicated by a PPE of which 28% required the placement of a chest drain. Statistically significant association was found between CRP levels and each of these outcomes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Incorporating CRP within a multivariate prediction model provided an area under the curve of up to 0.96.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRP can be a useful prognostic marker when evaluating a patient with suspected bacterial pneumonia and could help the paediatrician in identifying patients needing closer follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15580","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T10:37:04Z","timestamp":1600943824000},"page":"970-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The prognostic value of C\u2010reactive protein for children with pneumonia"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-4728","authenticated-orcid":false,"given":"Yuval","family":"Barak\u2010Corren","sequence":"first","affiliation":[{"name":"Pediatric Department Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Predictive Medicine Group Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Horovits","sequence":"additional","affiliation":[{"name":"Pediatric Department Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Predictive Medicine Group Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Erlichman","sequence":"additional","affiliation":[{"name":"Pediatric Department Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Predictive Medicine Group Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Picard","sequence":"additional","affiliation":[{"name":"Pediatric Department Shaare Zedek Medical Center Jerusalem Israel"},{"name":"School of Medicine Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Pneumonia [Internet]. 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Accessed February 16 2020"},{"key":"e_1_2_12_19_1","first-page":"323","article-title":"Factors associated with pneumonia severity in children: a systematic review","volume":"7","author":"Dean P","year":"2018","journal-title":"J Pediatr Infect Dis Soc"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.15580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.15580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:11:40Z","timestamp":1693278700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.15580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/apa.15580"],"URL":"https:\/\/doi.org\/10.1111\/apa.15580","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"assertion":[{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}