{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:16:38Z","timestamp":1761156998984,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The effect of ventilator modes on regional tissue oxygenation in premature neonates with respiratory distress syndrome (RDS) has yet to be delineated. Previous studies have looked at global oxygen delivery and have not assessed the effects on regional tissue oxygenation. Our aim in this study was to assess such tissue oxygenation in premature babies with RDS in relation to differing modes of ventilation using near\u2010infrared spectroscopy (NIRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 24 stable preterm infants with RDS, undergoing elective wean in ventilator mode, cerebral and muscle tissue oxygenation were assessed using NIRS. Infants were weaned from high\u2010frequency oscillator or jet ventilator to conventional invasive ventilation (CV) or extubated from CV to non\u2010invasive mechanical ventilation. Data at 30\u00a0minutes prior and at one hour after change in ventilator mode were compared (paired t test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In babies changed from high\u2010frequency oscillation to CV, jet to CV and CV to non\u2010invasive ventilation, the differences in cerebral NIRS (mean\u00a0\u00b1\u00a0<jats:italic>SD<\/jats:italic>) were 1.7\u00a0\u00b1\u00a09.9%, 2.3\u00a0\u00b1\u00a05.7% and 2.1\u00a0\u00b1\u00a08.4%, respectively. The concomitant changes in muscle NIRS were \u22122.9\u00a0\u00b1\u00a08.5%, 8.1\u00a0\u00b1\u00a09.7% and 3.6\u00a0\u00b1\u00a022.4%, respectively. No changes were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that there is no alteration in regional tissue oxygenation related to ventilator mode in stable preterm infants with improving RDS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15600","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T02:11:35Z","timestamp":1601345495000},"page":"1151-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of ventilator modes on neonatal cerebral and peripheral oxygenation using near\u2010infrared spectroscopy"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-4341","authenticated-orcid":false,"given":"Kristina","family":"Ericksen","sequence":"first","affiliation":[{"name":"Division of Perinatal\u2010Neonatal Medicine Maria Fareri Children\u2019s Hospital at Westchester Medical Center New York Medical College Valhalla, New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gad","family":"Alpan","sequence":"additional","affiliation":[{"name":"Division of Perinatal\u2010Neonatal Medicine Maria Fareri Children\u2019s Hospital at Westchester Medical Center New York Medical College Valhalla, New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund F.","family":"La Gamma","sequence":"additional","affiliation":[{"name":"Division of Perinatal\u2010Neonatal Medicine Maria Fareri Children\u2019s Hospital at Westchester Medical Center New York Medical College Valhalla, New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1007\/s001340050392"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1136\/adc.2006.103929"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1097\/00003246-200001000-00038"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.4187\/respcare.03486"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1007\/s00134-008-1298-y"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1136\/fn.74.3.F172"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1067\/S0022-3476(03)00359-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1097\/MD.0000000000002780"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1016\/j.jpeds.2013.10.087"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1007\/s00431-018-3096-z"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1152\/japplphysiol.00298.2015"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"Cerebral 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