{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:27Z","timestamp":1747183227067,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the factors associated with hypokalaemia and their outcomes, in severely malnourished children under 5\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We focused on 407 severely malnourished children under five who were admitted to the Dhaka Hospital, International Centre for Diarrhoeal Disease Research, Bangladesh, from April 2011 to June 2012. The cases were 139 with hypokalaemia, and the comparisons were 268 without hypokalaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cases were older than the comparisons, with a poor socio\u2010economic status and a higher death rate of 12% vs 7%. They were more likely to present with a history of measles, diarrhoea, lethargy, lower pulse rates, hyponatraemia, metabolic acidosis, hypocalcaemia, hypomagnesaemia, higher height or length, severe underweight, severe wasting and leucocytosis on admission. At discharge, cases had lower potassium levels and a higher proportion had persistent hypokalaemia. Cases received longer treatment with ampicillin and micronutrients. After adjusting for confounders, hypokalaemia was independently associated with poor socio\u2010economic status, diarrhoea, lower pulse rates, hypocalcaemia, metabolic acidosis and leucocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identifying simple clinical signs, like diarrhoea and lower pulse rates, and laboratory parameters, such as hypocalcaemia and metabolic acidosis, may enable the early management of hypokalaemia in severely malnourished children under 5\u00a0years. This could reduce morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15634","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T13:45:50Z","timestamp":1603374350000},"page":"1658-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early management of hypokalaemia in severely malnourished children under five could help to reduce deaths in developing countries"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-974X","authenticated-orcid":false,"given":"Abu Sadat Mohammad Sayeem Bin","family":"Shahid","sequence":"first","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmina","family":"Alam","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-3280","authenticated-orcid":false,"given":"Lubaba","family":"Shahrin","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Shahunja","sequence":"additional","affiliation":[{"name":"The University of Queensland  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monira","family":"Sarmin","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Afroze","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Waliur Rahman","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. 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