{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:18:56Z","timestamp":1780755536182,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the clinical course, outcome and incidence of infantile salt wasting associated with urinary tract infection (UTI) and\/or urinary tract malformation (UTM) over a two\u2010year surveillance period on the island of Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010year (2013\u201014) prospective surveillance undertaken via the Irish and Ulster Paediatric Surveillance Units. Monthly prepaid postcards were circulated to consultant paediatricians (n\u00a0=\u00a0260) at all paediatric units on the island of Ireland. Infants under one year of age presenting for the first time with hyponatraemia (Na\u00a0&lt;\u00a0130\u00a0mmol\/L) and\/or hyperkalaemia (K\u00a0&gt;\u00a05.0\u00a0mmol\/L) associated with urosepsis\/UTM were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 7 reported patients (6 male) had culture\u2010proven UTI, and 5 (71%) also had an underlying UTM (one diagnosed antenatally). Four (57%) patients had a documented elevated serum aldosterone supporting secondary pseudohypoaldosteronism (PHA) as the underlying diagnosis. Data on aldosterone were not reported in the other 3 patients, but clinical features were suggestive of secondary PHA. The estimated incidence for the Irish population of transient PHA is 1 per 13,200 total live births per year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salt wasting is a rare complication of UTI, especially if associated with underlying UTM. Boys appear to be at particular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15688","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T18:40:42Z","timestamp":1606502442000},"page":"1257-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-1770","authenticated-orcid":false,"given":"Abhidhamma","family":"Kaninde","sequence":"first","affiliation":[{"name":"Leicester Royal Infirmary Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana L.","family":"Grace","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Cork University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Cork University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman F.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Ghataore","sequence":"additional","affiliation":[{"name":"Principal Clinical Scientist Department of Biochemistry King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-0560","authenticated-orcid":false,"given":"Micheal F.","family":"Riordan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinologist Children\u2019s Health Ireland at Crumlin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Regional Hospital Mullingar Co Westmeath Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinologist Children\u2019s Health Ireland at Crumlin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12267"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.369"},{"key":"e_1_2_9_4_1","unstructured":"McDonnellC WhiteM KelleherS MurphyN.Congenital adrenal hyperplasia: incidence prevalence and rationale for inclusion on the newborn screening programme in the Republic of Ireland. 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