{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:57:22Z","timestamp":1754110642363,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Toll\u2010like receptor 1 (TLR1), TLR2, TLR6 and TLR10 form the TLR2 subfamily. In our previous controlled studies in 132 subjects with osteitis after newborn Bacillus Calmette\u2010Gu\u00e9rin (BCG) vaccination, <jats:italic>TLR1<\/jats:italic>, <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR6<\/jats:italic> variations were associated with the risk of BCG osteitis. Now, we evaluated the role of ten single nucleotide polymorphisms (SNP) of the <jats:italic>TLR10<\/jats:italic> gene in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five synonymous <jats:italic>TLR10<\/jats:italic> SNPs (rs10004195, rs10856837, rs10856838, rs1109695 and rs11466652), and five missense <jats:italic>TLR10<\/jats:italic> SNPs (rs11096955, rs11096957, rs11466649, rs11466653 and rs11466658) were determined by polymerase chain reaction (PCR)\u2010based sequencing in 132 former BCG osteitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>TLR10<\/jats:italic> rs10004195 polymorphism was associated with the risk of BCG osteitis, compared to Finnish population controls. The variant genotype (AT\/AA) was present in 13.6% of cases versus 26.2% of controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024). Correspondingly, the minor allele frequency (MAF) was lower (0.075) in cases than in controls (0.152; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). There were no significant differences in the genotypes of the other nine studied <jats:italic>TLR10<\/jats:italic> SNPs or in the corresponding MAFs between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among ten studied <jats:italic>TLR10<\/jats:italic> gene polymorphisms, the variation only in the <jats:italic>TLR10<\/jats:italic> rs10004195 was associated with the BCG osteitis risk after newborn BCG vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15720","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T12:22:56Z","timestamp":1607948576000},"page":"1585-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Toll\u2010like receptor 10<\/i> rs10004195 variation may be protective against Bacillus Calmette\u2010Gu\u00e9rin\u00a0osteitis after newborn vaccination"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-1919","authenticated-orcid":false,"given":"Matti","family":"Korppi","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Life Sciences Center for Child Health Research University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-7602","authenticated-orcid":false,"given":"Eero","family":"Lauhkonen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences Center for Child Health Research University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-9449","authenticated-orcid":false,"given":"Kirsi","family":"Nuolivirta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-6065","authenticated-orcid":false,"given":"Qiushui","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"},{"name":"Department of Medical Microbiology Capital Medical University Beijing 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