{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:42:03Z","timestamp":1790293323399,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Bumetanide, a diuretic agent, that reduces intracellular chloride\u2014thereby reinforcing GABAergic inhibition\u2014has been reported to improve core symptoms of autism in children. Given the positive results reported from French trials of bumetanide in children with autism, we decided to evaluate its effects in a small\u2010scale pilot study, in advance of a larger randomised controlled study (RCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an open\u2010label three\u2010month trial of bumetanide on six children (five boys), aged 3\u201314\u00a0years with autism. Ratings according to the Parental Satisfaction Survey (PASS) were used after four and twelve weeks to assess symptom change. Blood electrolyte status was monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvement in the PASS domain \u201cCommunicative and cognitive abilities\u201d was marked or very marked in four children, and two had some improvements. Few negative side effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our small cohort responded well to bumetanide, particularly with regard to \u201cCommunicative and cognitive abilities\u201d. Taken with the evidence from larger\u2010scale RCTs, we suggest that bumetanide should be considered for inclusion in ethically approved treatment\/management trials for children with autism, subject to rigorous follow\u2010up in large\u2010scale RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15723","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T14:36:41Z","timestamp":1608302201000},"page":"1548-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bumetanide for autism: Open\u2010label trial in six children"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-7747","authenticated-orcid":false,"given":"Elisabeth","family":"Fernell","sequence":"first","affiliation":[{"name":"Gillberg Neuropsychiatry Centre Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-7169","authenticated-orcid":false,"given":"Peik","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Department of Clinical Sciences Lund Medical Faculty Lund University Lund Sweden"},{"name":"Neuropsychiatry unit Department of Child and Adolescent Psychiatry in Malm\u00f6 Region Sk\u00e5ne Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gillberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"The autisms","author":"Coleman M","year":"2012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000979"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"CarlssonM.Autism and glutamate. 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