{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:29:53Z","timestamp":1754396993023,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2018\u20100101","ST2013\u20100008","TJ2014\u20100007"],"award-info":[{"award-number":["PR2018\u20100101","ST2013\u20100008","TJ2014\u20100007"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016412","name":"Mary B\u00e9ves Stiftelse f\u00f6r Barncancerforskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the prevalence of vitamin D deficiency among children with non\u2010haematological malignancies and to explore possible causes of low vitamin D levels among these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study of 458 children diagnosed with solid tumours, brain tumours, non\u2010Hodgkin lymphoma or Hodgkin disease at the University Children's Hospital, Uppsala, Sweden. Serum 25\u2010hydroxyvitamin D and parathyroid hormone levels were measured in samples taken at the time of cancer diagnosis and related to clinical data. Vitamin D deficiency was defined as a 25\u2010hydroxyvitamin D level below 50\u00a0nmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence rate of vitamin D deficiency among children with non\u2010haematological malignancies was 41%. There was no association between sex or diagnosis and vitamin D status. Vitamin D deficiency was more common among school children than preschool children (51% vs. 24%). Older age, season outside summer, and a more recent calendar year were significant predictors of lower 25\u2010hydroxyvitamin D. There was a significant, albeit weak, negative correlation between 25\u2010hydroxyvitamin D and parathyroid hormone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin D deficiency is common among children diagnosed with cancer, particularly among school\u2010aged children diagnosed outside summer. The prevalence appears to be increasing, underlining the need for adequate replacement of vitamin D in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15788","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T15:09:53Z","timestamp":1612537793000},"page":"2252-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of and factors influencing vitamin D deficiency in paediatric patients diagnosed with cancer at northern latitudes"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-3299","authenticated-orcid":false,"given":"Natalja","family":"Jackmann","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7540-438X","authenticated-orcid":false,"given":"Jan","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arja","family":"Harila\u2010Saari","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Ljungman","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dzeneta","family":"Nezirevic Dernroth","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Frisk","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institute, and Clinical Genetics Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"101733","DOI":"10.1016\/j.canep.2020.101733","article-title":"Childhood cancer: Survival, treatment modalities, late effects and improvements over time","volume":"71","author":"Erdmann F","year":"2020","journal-title":"Cancer Epidemiol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1001\/jama.2013.6296"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1210\/jc.84.12.4702"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1007\/s11914-013-0165-0"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1007\/s00198-011-1605-2"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.4065\/81.3.353"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1371\/journal.pone.0040090"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1093\/ajcn\/79.3.362"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1210\/en.2011-0243"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1016\/j.clnu.2014.12.023"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1097\/MPG.0000000000001028"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1542\/peds.107.4.e53"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1002\/pbc.28163"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1097\/MPG.0b013e31828f3c05"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1210\/jc.2011-0385"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1097\/MPH.0b013e31829f3754"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1371\/journal.pone.0060856"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1016\/j.bonr.2016.03.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1097\/MPG.0b013e3182838e5b"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1136\/adc.2009.173195"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1111\/apa.14835"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1016\/j.ejca.2019.06.016"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1159\/000482009"},{"unstructured":"Livsmedelsverket [Internet].https:\/\/www.livsmedelsverket.se\/livsmedel\u2010och\u2010innehall\/naringsamne\/vitaminer\u2010och\u2010antioxidanter\/d\u2010vitamin. 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