{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:35:46Z","timestamp":1780432546795,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This national retrospective Danish study described the characteristics of children diagnosed with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, an inherited X\u2010linked recessive disorder that often affects children of Middle Eastern descent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied children born between 1 January 2000 and 31 December 2017 and diagnosed with G6PD deficiency. They were identified from the Danish National Hospital Discharge Register and the Danish Database of Extreme Neonatal Hyperbilirubinaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 113 children diagnosed with G6PD deficiency, 67% were of Middle Eastern descent and they were frequently diagnosed before the onset of symptoms, based on known heredity. Of the 67 infants born in Denmark, 10% had extreme neonatal hyperbilirubinaemia and one developed kernicterus spectrum disorder, as did one child born in the Middle East. Most (61%) of the 33 children with jaundice received phototherapy, 12% had exchange transfusions and 18% received whole blood transfusions. After the neonatal period, 23% of the cohort had blood transfusions and 4% needed intensive care for acute haemolytic anaemia. The incidence of G6PD deficiency appeared to be severely underestimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Many families from countries where G6PD deficiency is endemic move to Denmark and other Western countries. Greater awareness is essential to avoid chronic and potentially lethal, consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15803","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T06:56:53Z","timestamp":1612940213000},"page":"1935-1941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A greater awareness of children with glucose\u20106\u2010phosphate dehydrogenase deficiency is imperative in western countries"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-0321","authenticated-orcid":false,"given":"Line","family":"Kristensen","sequence":"first","affiliation":[{"name":"Regional Hospital Central Jutland Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda BK.","family":"Lai","sequence":"additional","affiliation":[{"name":"Region Hospital Horsens Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Ebbesen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette L.","family":"Donneborg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The North Denmark Region Hospital Hj\u00f8rring Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Centre for Clinical Research The North Denmark Regional Hospital Hj\u00f8rring Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/beha.1999.0055"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"557","article-title":"Efficacy of clofibrate on severe neonatal jaundice associated with glucose\u20106\u2010phosphate dehydrogenase deficiency (a randomized clinical trial)","volume":"39","author":"Zahedpasha Y","year":"2008","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.09.001"},{"issue":"7","key":"e_1_2_10_6_1","first-page":"1277","article-title":"Diagnosis and management of G6PD deficiency","volume":"72","author":"Frank JE","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-017-0330-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1165-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489820"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.12128"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12735"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf426"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"Treatment standard for neonatal hyperbilirubinemia","volume":"1","author":"Vandborg P","year":"2019","journal-title":"Danish Paediatr Soc"},{"key":"e_1_2_10_15_1","volume-title":"Immigrants and Descendants","author":"Denmark\u2019s Statistics","year":"2018"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198702000-00019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.714"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000435"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2015.1031692"},{"issue":"6","key":"e_1_2_10_20_1","first-page":"601","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency. 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