{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:35:40Z","timestamp":1787956540703,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The global incidence of type 1 diabetes mellitus (T1DM) varies considerably geographically. Ireland has a high incidence of T1DM. Incidence accelerated between 1997 and 2008, although more recent data (2008\u20132013) suggested stabilisation in the incidence rate (IR). This study sought to determine IRs for 2014 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Incident cases were prospectively recorded through the established Irish Childhood Diabetes National Register (ICDNR). Cases were verified, and IRs were calculated. Capture\u2010recapture methodology was identical to previous studies. Age and seasonality data were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1429 cases were reported (age range 0.45\u201314.98\u00a0years), with significantly more males (772, 54%) and male\u2010to\u2010female ratio of 1.17 (95% CI 1.05, 1.29). Standardised IRs for T1DM in the period were 28.0; 29.6; 30.9; 27.0; and 27.1\/100,000\/year, respectively. There was a slight reduction in standardised IR, more marked in females than males (9.9% v 1.6%). The highest IR remains in the 10\u2010 to 14\u2010year\u2010old age group (44% of total cases). Seasonality of diagnosis is persistently higher in autumn and winter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ireland remains a high incidence country, despite a minor reduction in incidence rates. Ongoing incidence monitoring through national registers is vital to inform healthcare services, research relating to aetiology and paediatric diabetes management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.15836","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T13:04:40Z","timestamp":1615381480000},"page":"2142-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Incidence of childhood type 1 diabetes mellitus in Ireland remains high but no longer rising"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-7221","authenticated-orcid":false,"given":"Amanda","family":"McKenna","sequence":"first","affiliation":[{"name":"The Department of Paediatrics Trinity College Dublin The University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra","family":"O'Regan","sequence":"additional","affiliation":[{"name":"The Department of Statistics Trinity College Dublin The University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Ryder","sequence":"additional","affiliation":[{"name":"The National Immunisation Office  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"The Department of Paediatric Growth, Diabetes and Endocrinology Children\u2019s Health Ireland (CHI) at Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Hoey","sequence":"additional","affiliation":[{"name":"The Department of Paediatrics Trinity College Dublin The University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Roche","sequence":"additional","affiliation":[{"name":"The Department of Paediatrics Trinity College Dublin The University of Dublin  Dublin Ireland"},{"name":"The Department of Paediatric Growth, Diabetes and Endocrinology Children\u2019s Health Ireland (CHI) at Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12758"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3090-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0813"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2787-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0604"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13345"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00799.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4763-3"},{"issue":"9","key":"e_1_2_11_10_1","first-page":"278","article-title":"The incidence of childhood type 1 diabetes in Ireland and the National Childhood Diabetes Register","volume":"107","author":"Roche EF","year":"2014","journal-title":"Ir Med J"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3709-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12566"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00826.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.5456"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12949"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.8.1191"},{"key":"e_1_2_11_17_1","unstructured":"WHO Multinational Project for Childhood Diabetes (Diabetes Mondiale).Diamond study method of operations version 2 Parts I\u2010IV.1991."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.2.528"},{"key":"e_1_2_11_19_1","first-page":"278","volume-title":"Interpretation and Use of Medical Statistics","author":"Daly LE","year":"1991"},{"key":"e_1_2_11_20_1","unstructured":"Central Statistics Office.Population estimates from 1926 (Number) by sex single year of age and year. 2019103108813577820 PEA 113660940.2019. 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