{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:16:39Z","timestamp":1785500199814,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal encephalopathy (NE) is associated with altered cognitive, motor, sensory abilities and behavioural outcomes. This case\u2010control study aimed to assess whether Quality of Life (QoL) and sleep disorders are affected in older children following NE compared to age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children at school\u2010age post\u2010NE were recruited and compared to age\u2010matched controls. Sleep and QoL were assessed with the Pediatric Quality of Life Inventory and the Child Sleep Habit Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred children were recruited with an age range of 4\u20136\u00a0years, including children post\u2010NE (n=45) and age\u2010matched controls (n\u00a0=\u00a055). Significantly higher pathological sleep scores were evident in 58% of children post\u2010NE compared to controls (43.8 vs 40.2; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Children post\u2010NE had increased bedtime resistance (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) and sleep anxiety (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) compared to controls. Children in the post\u2010NE group had lower total QoL scores versus controls (mean score 82.5 vs 95.8; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Children with mild NE also had lower total QoL scores than controls (90.0 vs 95.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). There was a strong correlation between low QoL with high total sleep scores (Rho 0.339, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were high rates of sleep issues in school\u2010aged children with mild and moderate\u2010severe NE. Consideration and management of sleep problems may improve QoL in childhood post\u2010NE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15902","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T01:59:16Z","timestamp":1620093556000},"page":"2352-2356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An observational study of sleep in childhood post\u2010neonatal encephalopathy"],"prefix":"10.1111","volume":"110","author":[{"given":"Zunera","family":"Zareen","sequence":"first","affiliation":[{"name":"Discipline of Paediatrics Trinity College The University of Dublin Dublin Ireland"},{"name":"Trinity Translational Medicine Institute (TTMI) &amp; Trinity Research in Childhood Centre (TRiCC) Trinity College Dublin Dublin Ireland"},{"name":"Paediatrics Children\u2019s Health Ireland (CHI) at Tallaght Dublin Ireland"},{"name":"Paediatrics National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-3031","authenticated-orcid":false,"given":"John","family":"Allen","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics Trinity College The University of Dublin Dublin Ireland"},{"name":"Paediatrics Children\u2019s Health Ireland (CHI) at Tallaght Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1143","authenticated-orcid":false,"given":"Lynne A.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics Trinity College The University of Dublin Dublin Ireland"},{"name":"Trinity Translational Medicine Institute (TTMI) &amp; 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