{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:05Z","timestamp":1747183265814,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Dutch national guidelines on follow\u2010up of paediatric celiac disease (CD) are available. The primary aim was to evaluate guideline adherence by paediatricians during follow\u2010up. The secondary aim was to determine the clinical relevance and diagnostic yield of routine laboratory tests suggested by these guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, single\u2010centre, cohort study was performed in paediatric CD patients who visited Tergooi Hospital, the Netherlands, between January 2017 and December 2019, with follow\u2010up of at least twelve months after diagnosis. We analysed guideline adherence, number of outpatient visits and all laboratory data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 91 CD children with a median follow\u2010up of 4.0\u00a0years (range 1\u201316\u00a0years) and 162 follow\u2010up visits. Strict adherence amongst paediatricians during follow\u2010up was 8.0% (13\/162 cases). A total of 1570\u00a0laboratory tests were performed of which 45.4% (713\/1570) was in strict compliance with the Dutch national guidelines. Clinically relevant deviations were observed in 5.3% of requested laboratory tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Strict guideless adherence amongst paediatricians in follow\u2010up of paediatric CD was low and the clinical relevance of the suggested routine laboratory tests is limited. This underlines the increasing notion that evidence\u2010based guidelines on follow\u2010up of CD are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.15967","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T22:58:25Z","timestamp":1622761105000},"page":"2641-2647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Guideline adherence and clinical relevance of laboratory investigations during follow\u2010up in paediatric coeliac disease: A Dutch single\u2010centre cohort study"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-4525","authenticated-orcid":false,"given":"Michael W.","family":"van Kalleveen","sequence":"first","affiliation":[{"name":"Department of Paediatrics Tergooi Hospital Blaricum The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim C.","family":"Dykstra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Tergooi Hospital Blaricum The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim G. J.","family":"de Meij","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-2048","authenticated-orcid":false,"given":"Frans B.","family":"Pl\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Tergooi Hospital Blaricum The Netherlands"},{"name":"Department of Paediatrics Amsterdam UMC Emma Children\u2019s Hospital University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3103-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001532"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2018.09.004"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"Coeliac disease","volume":"5","author":"Lindfors K","year":"2019","journal-title":"Nat Rev Dis Prim"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000227275"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1238-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2018.09.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.046"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101424"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001480"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"362","article-title":"Normalization Time of Celiac Serology in Children on a Gluten\u2010free Diet","volume":"64","author":"Gidrewicz D","year":"2017","journal-title":"J Pediatr"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3762"},{"key":"e_1_2_9_15_1","first-page":"1","article-title":"Two decades of pediatric celiac disease in a tertiary referral center: What has changed?","author":"Krauthammer A","year":"2020","journal-title":"Dig Liver Dis"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200501000-00001"},{"key":"e_1_2_9_18_1","article-title":"Richtlijn Coeliakie en Dermatitis Herpetiformis","author":"CBO","year":"2008","journal-title":"Haarlem: Nederlandse Vereniging van Maag\u2010Darm\u2010Leverartsen"},{"key":"e_1_2_9_19_1","unstructured":"NVKC.Algemeen overzicht referentiewaarden Nederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde. 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