{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:17Z","timestamp":1747183277005,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of nutritional supplementation on height, weight and body composition in short and lean male preadolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised, double\u2010blinded, placebo\u2010controlled trial of nutritional supplementation of short and lean prepubertal 10\u201314.5\u2010year\u2010old boys. Primary outcomes included \u0394height\u2010SDS and \u0394weight\u2010SDS. Secondary outcomes included changes in body composition and BMI\u2010SDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 160 boys enrolled, 126 (80%) completed 6\u00a0months\u2019 intervention. Baseline age, height\u2010SDS, weight\u2010SDS, BMI\u2010SDS, body composition and dietary intake were similar in the formula and placebo groups. \u2018Good\u2019 formula consumers (intake of \u226550% of the recommended dose, <jats:italic>n<\/jats:italic>\u00a0=\u00a030) gained significantly more in weight\u2010SDS, BMI\u2010SDS, fat\u2010free\u2010mass and muscle mass (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) than did \u2018poor\u2019 consumers (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) and the placebo group (<jats:italic>n\u00a0<\/jats:italic>=\u00a061). Only in the formula group, positive dose\u2010response correlations were found between consumption of the formula and changes in the outcome parameters examined, including \u0394height\u2010SDS (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.301, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.015). Boys aged &gt;11.4\u00a0years who were \u2018good\u2019 formula consumers maintained their \u0394height\u2010SDS, while \u0394height\u2010SDS declined in \u2018poor\u2019 consumers and the placebo group of the same age (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intervention with a multi\u2010nutrient, protein\u2010rich formula was effective in increasing weight\u2010SDS, fat\u2010free\u2010mass, muscle mass and BMI\u2010SDS in short and lean prepubertal male adolescents. Good consumption of the formula prevented \u0394height\u2010SDS decline in the older participants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16054","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:53:10Z","timestamp":1628067190000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of a nutritional supplementation on growth and body composition in short and lean preadolescent boys: A randomised, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"111","author":[{"given":"Naama","family":"Fisch Shvalb","sequence":"first","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liora","family":"Lazar","sequence":"additional","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Demol","sequence":"additional","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Mouler","sequence":"additional","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Rachmiel","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Pediatric Endocrinology Unit Shamir (Assaf Harofeh) Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Hershkovitz","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes Unit Soroka Medical Center Beer\u2010Sheva affiliated with Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Schneider Children's Medical Center Institute for Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-5033","authenticated-orcid":false,"given":"Michal","family":"Yackobovitch\u2010Gavan","sequence":"additional","affiliation":[{"name":"National Center for Childhood Diabetes Schneider Children's Medical Center of Israel The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(02)90418-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2020.1717615"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000317440"},{"volume-title":"Growth at Adolescence, 2nd ed","year":"1962","author":"Tanner JM","key":"e_1_2_10_5_1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0430-0"},{"key":"e_1_2_10_7_1","first-page":"40","volume-title":"Clinical Nutrition. 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