{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:52:21Z","timestamp":1790833941265,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Prediction models may be useful in accurately identifying children who will benefit from growth hormone (GH) treatment. We aimed to validate the Gothenburg prediction model for this purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included prepubertal children with GH deficiency who started treatment with GH during 2004\u20102016 at Queen Silvia Children's Hospital, Gothenburg, based on a first\u2010year growth prediction of \u22650.7\u00a0SDS in height according to the Gothenburg prediction model on a GH dose of 33\u00a0\u03bcg\/kg\/day. Observed heights retrieved from medical charts were compared with predicted heights.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 121 patients (64% boys) with at least one year of data after the start of GH treatment. The median (range) GH dose was 30 (10\u201343)\u00a0\u00b5g\/kg\/day for the first year and age at start of treatment was 5.32 (3\u201311.8)\u00a0years. The model correctly excluded poor responders resulting in 119\/121 (98%) patients having a height gain of at least \u22650.5 SDS in a year. However, the model underestimated relatively low predictions and overestimated relatively high predictions, with a residual standard deviation of 0.31 SDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By using a validated prediction model for GH in a clinical context, unnecessarily treating short children with an expected poor height outcome can be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16070","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T17:38:29Z","timestamp":1629308309000},"page":"346-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A prediction model could foresee adequate height response in children eligible for growth hormone treatment"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-301X","authenticated-orcid":false,"given":"Helena\u2010Jamin","family":"Ly","sequence":"first","affiliation":[{"name":"Department of Pediatrics G\u00f6teborg Pediatric Growth Research Center Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Fors","sequence":"additional","affiliation":[{"name":"Department of Pediatrics G\u00f6teborg Pediatric Growth Research Center Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics G\u00f6teborg Pediatric Growth Research Center Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Laboratory Medicine Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-3439","authenticated-orcid":false,"given":"Jovanna","family":"Dahlgren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics G\u00f6teborg Pediatric Growth Research Center Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184851"},{"issue":"11","key":"e_1_2_9_3_1","first-page":"3990","article-title":"Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research 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