{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:06:05Z","timestamp":1789610765998,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe incidence and outcome of acute kidney injury (AKI) in infants with hypothermia\u2010treated hypoxic\u2010ischaemic encephalopathy (HIE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational population\u2010based study included all term and near\u2010term infants with hypothermia\u2010treated HIE born between 2007 and 2009 in greater Stockholm. The KDIGO definition modified for neonatal patients was used to identify infants with AKI. We analysed association between AKI and neonatal morbidity\/mortality. Furthermore, we calculated estimated glomerular filtration rate (eGFR) at the age of 10\u201312\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 83,939\u00a0live births in the Stockholm region, 66 infants underwent hypothermia treatment due to HIE. Out of 65 included infants, 45% suffered AKI. Degree of AKI correlated with HIE severity. One infant needed kidney replacement therapy; others were treated conservatively. AKI was associated with increased mortality and need for blood products (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). eGFR at age 10\u201312\u00a0years was available for 72% of survivors. Nine children (21%) had subnormal eGFR, with no difference between those with and without a history of neonatal AKI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite therapeutic hypothermia, AKI remains a common complication in infants with HIE and is associated with increased neonatal mortality. Twenty\u2010one per cent of children had subnormal eGFR at 10\u201312\u00a0years, highlighting the need for long\u2010term follow\u2010up of renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.16078","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T07:08:11Z","timestamp":1629875291000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Acute kidney injury in infants with hypothermia\u2010treated hypoxic\u2010ischaemic encephalopathy: An observational population\u2010based study"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-6470","authenticated-orcid":false,"given":"Katarina","family":"Robertsson Grossmann","sequence":"first","affiliation":[{"name":"Division of Paediatrics Department of Clinical Science, Intervention and Technology Karolinska Institutet, and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6501-8293","authenticated-orcid":false,"given":"Peter","family":"B\u00e1r\u00e1ny","sequence":"additional","affiliation":[{"name":"Division of Paediatrics Department of Clinical Science, Intervention and Technology Karolinska Institutet, and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-0261","authenticated-orcid":false,"given":"Mats","family":"Blennow","sequence":"additional","affiliation":[{"name":"Division of Paediatrics Department of Clinical Science, Intervention and Technology Karolinska Institutet, and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-057X","authenticated-orcid":false,"given":"Milan","family":"Chromek","sequence":"additional","affiliation":[{"name":"Division of Paediatrics Department of Clinical Science, Intervention and Technology Karolinska Institutet, and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst 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